Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1
Cell Reports, 2016 Sister chromatid cohesion is mediated by cohesin, whose Smc1, Smc3, and kleisin (Scc1) subunits form a ring structure that entraps sister DNAs. The ring is opened either by separase, which cleaves Scc1 during anaphase, or by a releasing activity ...
Byung-Gil Lee +6 more
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Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA. [PDF]
, 2019 Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Chatterjee, Fiona +3 more
core +1 more source
Identification of Xenopus SMC protein complexes required for sister chromatid cohesion [PDF]
, 1998 The structural maintenance of chromosomes (SMC) family is a growing family of chromosomal ATPases. The founding class of SMC protein complexes, condensins, plays a central role in mitotic chromosome condensation. We report here a new class of SMC protein
Hirano, M., Hirano, T., Losada, A.
core +2 more sources
The Making and Breaking of Sister Chromatid Cohesion [PDF]
Cell, 2001 The picture that emerges from recent studies is that of an intricate regulatory network, the purpose of which is to ensure that sister chromatids go their separate ways during anaphase. The more we know about the process, the more challenging our next questions become.
openaire +2 more sources
Dynamic molecular linkers of the genome: the first decade of SMC proteins [PDF]
, 2005 Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly conserved from bacteria to humans, that play fundamental roles in many aspects of higher-order chromosome organization and dynamics.
Hirano, T., Losada, A.
core +1 more source
The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion and repair [PDF]
, 2002 The first draft of the human genome sequence was reported a year ago. It may be a good time to remind ourselves that the genetic information encoded in the ∼3000-Mb sequence is stored not only in the public or private databases but also in the tiny space
Hirano, T.
core +1 more source
Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction [PDF]
, 2018 SummaryWhen human cells enter mitosis, chromosomes undergo substantial changes in their organisation to resolve sister chromatids and compact chromosomes.
Eykelenboom, John K +7 more
core +2 more sources
Epigenetic regulation of Mash1 expression [PDF]
, 2010 Mash1 is a proneural gene important for specifying the neural fate. The Mash1 locus undergoes specific epigenetic changes in ES cells following neural induction.
Beretta, Chiara, Beretta, Chiara
core +1 more source
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
eLife, 2017 Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction
Petra van der Lelij +17 more
doaj +1 more source
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.
PLoS Biology, 2005 Cohesion between sister chromatids is essential for their bi-orientation on mitotic spindles. It is mediated by a multisubunit complex called cohesin.
Barry E McGuinness +4 more
doaj +1 more source