Targeted sister chromatid cohesion by Sir2. [PDF]
PLoS Genetics, 2011 The protein complex known as cohesin binds pericentric regions and other sites of eukaryotic genomes to mediate cohesion of sister chromatids. In budding yeast Saccharomyces cerevisiae, cohesin also binds silent chromatin, a repressive chromatin ...
Ching-Shyi Wu +2 more
doaj +4 more sources
A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres [PDF]
The EMBO JournalThe 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer kinetochore.
Lu Yan +12 more
doaj +2 more sources
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]
PLoS Genetics, 2018 Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone +8 more
doaj +3 more sources
Reduced sister chromatid cohesion acts as a tumor penetrance modifier. [PDF]
PLoS Genetics, 2022 Sister chromatid cohesion (SCC) is an important process in chromosome segregation. ESCO2 is essential for establishment of SCC and is often deleted/altered in human cancers.
Jun Wang +9 more
doaj +2 more sources
Regulation of Centromere Localization of the Drosophila Shugoshin MEI-S332 and Sister-Chromatid Cohesion in Meiosis [PDF]
, 2014 The Shugoshin (Sgo) protein family helps to ensure proper chromosome segregation by protecting cohesion at the centromere by preventing cleavage of the cohesin complex. Some Sgo proteins also influence other aspects of kinetochore-microtubule attachments.
Cristina Nogueira +4 more
openalex +4 more sources
Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. [PDF]
PLoS Genetics, 2019 Cohesin acetyltransferases ESCO1 and ESCO2 play a vital role in establishing sister chromatid cohesion. How ESCO1 and ESCO2 are controlled in a DNA replication-coupled manner remains unclear in higher eukaryotes. Here we show a critical role of CUL4-RING
Haitao Sun +7 more
doaj +2 more sources
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. [PDF]
PLoS Genetics, 2009 Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood.
Raffaella Nativio +9 more
doaj +4 more sources
Sister chromatid cohesion. [PDF]
Cold Spring Harb Perspect Biol, 2012 During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation.
Peters JM, Nishiyama T.
europepmc +8 more sources
Symmetric control of sister chromatid cohesion establishment. [PDF]
Nucleic Acids Res, 2023 Abstract Besides entrapping sister chromatids, cohesin drives other high-order chromosomal structural dynamics like looping, compartmentalization and condensation. ESCO2 acetylates a subset of cohesin so that cohesion must be established and only be established between nascent sister chromatids.
Zhang J +14 more
europepmc +3 more sources
Nature Communications, 2017 Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase ...
Petros Marangos, John Graham Carroll
exaly +2 more sources