Results 31 to 40 of about 18,693 (245)
Matchmakers for sister-chromatid cohesion [PDF]
Nature Cell Biology, 2000 Barbara Marte
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Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2016 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco +11 more
core +6 more sources
S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit
mBio, 2022 During DNA replication, the newly created sister chromatids are held together until their separation at anaphase. The cohesin complex is in charge of creating and maintaining sister chromatid cohesion (SCC) in all eukaryotes.
Karan Choudhary +6 more
doaj +1 more source
Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2014 High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
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eLife, 2022 Cohesin organizes the genome by forming intra-chromosomal loops and inter-sister chromatid linkages. During gamete formation by meiosis, chromosomes are reshaped to support crossover recombination and two consecutive rounds of chromosome segregation ...
Rachael E Barton +3 more
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Cohesin: Functions beyond sister chromatid cohesion [PDF]
FEBS Letters, 2013 Faithful segregation of chromosomes during mitosis and meiosis is the cornerstone process of life. Cohesin, a multi‐protein complex conserved from yeast to human, plays a crucial role in this process by keeping the sister chromatids together from S‐phase to anaphase onset during mitosis and meiosis.
Mehta, Gunjan D. +3 more
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Chromatid Cohesion: Acetylation Joins the Sisters [PDF]
Current Biology, 2008 The replication-fork-associated protein Eco1 is required for the establishment of sister chromatid cohesion, which plays an essential role in faithful chromosome segregation. Three recent studies in yeast and humans reveal that the acetyltransferase activity of Eco1 targets the cohesin subunit Smc3 to facilitate the establishment of cohesion.
Tanaka, Koichi, Watanabe, Yoshinori
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Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability [PDF]
, 2019 Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells.
Benstead-Hume, Graeme +7 more
core +2 more sources
Genome Biology, 2022 Background Cohesin is a chromosome-associated SMC–kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis.
Eui-Hwan Choi +7 more
doaj +1 more source
Sister chromatid cohesion establishment during DNA replication termination. [PDF]
ScienceNewly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion coordinates with DNA replication is poorly understood. Prevailing models suggest that cohesin complexes, bound to DNA before replication, remain behind the advancing replication fork to keep sister chromatids together.
Cameron G +8 more
europepmc +5 more sources