Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Phosphate Accelerates Cellular Cholesterol Efflux in THP-1 Cells [PDF]
Biomolecules, 2023 Cholesterol efflux is a major atheroprotective function of high-density lipoproteins (HDLs) which removes cholesterol from the foam cells of lipid-rich plaques in Type 2 diabetes.
Tomohiro Komatsu +7 more
doaj +7 more sources
Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization [PDF]
Frontiers in EndocrinologyAimTo investigate the effect and mechanism of Sitagliptin phosphate on inflammation and macrophage polarization in a mouse model of type 2 diabetes.MethodsIn vitro, Raw264.7 cells were cultured with a high concentration of glucose (HG) and sitagliptin ...
Xiaoxia Hu, Yalong Li, Xinyue Liu
doaj +7 more sources
Stability of extemporaneously prepared sitagliptin phosphate solution. [PDF]
PLoS ONE, 2022 Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used orally in conjunction with diet and exercise to control sugar levels in type 2 Diabetes Mellitus patients.
Abdel Naser Zaid +7 more
doaj +6 more sources
Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model [PDF]
Scientific Reports, 2023 The solubility of an anti-hyperglycemic agent drug, (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4] triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine (also known as Sitagliptin phosphate) in supercritical carbon dioxide ...
Nedasadat Saadati Ardestani +4 more
doaj +5 more sources
Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate [PDF]
Molecules, 2018 Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine ...
Haoling Gao +3 more
doaj +6 more sources
Drug Analytical Research, 2023 Sitagliptin phosphate (STG), used for the treatment of type 2 diabetes, is a drug that belongs to a new class called inhibitors of dipeptidyl peptidase IV (DPPIV). It is known to be the first agent of the class approved by the FDA.
Alini Dall Cortivo Lange +3 more
doaj +4 more sources
RNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats. [PDF]
Evid Based Complement Alternat Med, 2020 Diabetes is one of the most serious chronic diseases. Numerous drugs including oral agents and traditional Chinese medicines, such as sitagliptin phosphate (SP) and Fuzhujiangtang granules (FJG), have been discovered to treat diabetes and used in ...
Guo X +6 more
europepmc +4 more sources
Two methods for the preparation of sitagliptin phosphate via chemical resolution and asymmetric hydrogenation. [PDF]
RSC Adv, 2021 Two effective processes have been developed for the preparation of sitagliptin phosphate. The approach of chemical resolution obtained R-sitagliptin in five steps from commercially available starting materials using the inexpensive NaBH4 to reduce the ...
Ye F +5 more
europepmc +5 more sources
A Simple and Sensitive HPTLC Method for Simultaneous Determination of Metformin Hydrochloride and Sitagliptin Phosphate in Tablet Dosage Form [PDF]
Journal of Chemistry, 2013 A simple, rapid, and precise high-performance thin-layer chromatographic (HPTLC) method for simultaneous estimation of two antidiabetic drugs, metformin hydrochloride and sitagliptin phosphate, in tablet dosage form has been developed and validated ...
Darshana K. Modi +2 more
doaj +5 more sources
Pharmacokinetics and Bioequivalence of Sitagliptin Phosphate/Metformin Hydrochloride Tablets in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Study. [PDF]
Drugs R D, 2022 Our objective was to evaluate the pharmacokinetics and bioequivalence of test and reference (JANUMET®) formulations of sitagliptin phosphate/metformin hydrochloride tablets at a single dose of 50 mg/850 mg.
Shi P +9 more
europepmc +4 more sources