Is Transdermal Delivery Potential Route for Sitagliptin Phosphate: The pH Control Effect
Future Journal of Pharmaceuticals and Health Sciences, 2023 The objective of this study is to predict transdermal delivery as a potential route for sitagliptin phosphate. The partition coefficient of sitagliptin phosphate was measured in a chloroform-buffer system using the shake flask method at room temperature,
Chika J Mbah +2 more
semanticscholar +4 more sources
Pharmaceutical Development and Technology, 2022 Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets.
Daniel Żakowiecki +5 more
semanticscholar +4 more sources
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate [PDF]
Journal of Pharmaceutical Sciences, 2021 Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing ...
Naseem A. Charoo +13 more
semanticscholar +4 more sources
Formulation, Development and Characterization of Transdermal Patches of Sitagliptin Phosphate
Journal of Drug Delivery and Therapeutics, 2019 Sitagliptin is a dipeptidyl peptidase 4-(DPP-4) inhibitor with glucose controlling capabilities that was effectively used for treating diabetes in the past. However, the oral administration of this drug caused such severe side effects that it was removed
Kavita Varma Shukla +2 more
semanticscholar +4 more sources
Improved Chromatographic Separation of Sitagliptin Phosphate and Metformin Hydrochloride. [PDF]
Int J Biomed Sci, 2015 New UPLC method was developed for determination of sitagliptin and metformin using Symmetry C18 column (100 mm × 2.1 mm, 2.2 μm) and isocratic elution (methanol 20%), pH (3.5) as a mobile phase. The ultraviolet detector was operated at 220 nm and the column temperature was 50°C. Linearity parameters were acceptable over the concentration ranges of 2-12
Hendy MS.
europepmc +5 more sources
Development and Validation of Analytical Methods for Simultaneous Estimation of Sitagliptin Phosphate and Pioglitazone Hydrochloride [PDF]
International Journal for Pharmaceutical Research Scholars, 2018 Simple, rapid, accurate and precise UV spectrophotometric and RP-HPLC methods had been developed for simultaneous estimation of Sitagliptin Phosphate (STG) and Pioglitazone Hydrochloride (PIO). The method applied was Simultaneous Equation Method (Vierodt’
K. G. Vaishnavi +4 more
semanticscholar +3 more sources
International Journal of Research in Pharmacy and Allied ScienceThe proposed RP- HPLC method using QbD approach provides simple accurate, and reproducible quality analysis for determination of Sitagliptin phosphate. 32 factorial design were used. study interaction of 2 factors were selected as dependent variables i.e
Syed Abdul Hamid +4 more
semanticscholar +3 more sources
Pharmacokinetics and Bioequivalence of Sitagliptin Phosphate/Metformin Hydrochloride Tablets in Healthy Chinese Subjects: A Randomized, Open, Crossover Study [PDF]
, 2021 Objective To evaluate the pharmacokinetics and bioequivalence between Sitagliptin Phosphate/metformin Hydrochloride Tablets (test formulation) at a single dose of 50mg/850mg and Sitagliptin Phosphate/metformin Hydrochloride Tablets (reference ...
Ping Shi +9 more
openalex +2 more sources
A randomized, double-blind, active-controlled trial assessing the efficacy and safety of a fixed-dose combination (FDC) of MEtformin hydrochloride 1000 mg ER, SItagliptin phosphate 100 mg, and DApagliflozin propanediol 10 mg in Indian adults with type 2 diabetes: The MESIDA trial [PDF]
International Journal of Diabetes in Developing CountriesObjective To assess the efficacy and safety of fixed-dose combinations (FDC) of triple-drug dapagliflozin, sitagliptin, and metformin (DSM) compared with FDC of two-drug sitagliptin and metformin (SM), in Indian adult patients with type 2 diabetes (T2D).
Awadhesh Kumar Singh +35 more
openalex +2 more sources
Simultaneous UV Spectrophotometric Method for Estimation of Sitagliptin Phosphate and Metformin Hydrochloride in Bulk and Tablet Dosage Form [PDF]
International Journal For Multidisciplinary Research, 2022 Two simple, precise and economical UV methods have been developed for the simultaneous estimation of Sitagliptinphosphate and Metformin hydrochloride in bulk and pharmaceutical dosage form.
Sahil Latif Mansuri -
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