Results 241 to 250 of about 283,041 (288)
Adaptive Spo11 RNA editing gate optimizes meiosis I pace and mitotic proliferation while preserving ascospore formation. [PDF]
Sci AdvWu M +8 more
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Site-specific recombination and circular chromosome segregation
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995 Abstract The Xer site-specific recombination system functions in Escherichia coli to ensure that circular plasmids and chromosomes are in the monomeric state prior to segregation at cell division. Two recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E.
D J, Sherratt +6 more
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Inducible site‐specific recombination in myelinating cells
genesis, 2002 AbstractSummary: To explore the function of genes expressed by myelinating cells we have developed a model system that allows for the inducible ablation of predetermined genes in oligodendrocytes and Schwann cells. The Cre/loxP recombination system provides the opportunity to generate tissue‐specific somatic mutations in mice.
Doerflinger, Nathalie +2 more
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EMBO Journal, 1997 Xer site‐specific recombination at ColE1 cer converts plasmid multimers into monomers, thus ensuring the heritable stability of ColE1. Two related recombinase proteins, XerC and XerD, catalyse the strand exchange reaction at a 30 bp recombination core ...
David J Sherratt, S D Colloms
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Nature, 1981
Site-specific recombination is a reaction in which a pair of genetically defined sites undergoes reciprocal exchange (“crossing-over”) via a recombinase-mediated DNA breakage and joining process. Such reactions have a wide range of biological outcomes, from integration and excision of virus genomes into and out of host chromosomes, to acquisition of ...
David Sherratt, Avril Arthur, Paul Dyson
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Site-specific recombination is a reaction in which a pair of genetically defined sites undergoes reciprocal exchange (“crossing-over”) via a recombinase-mediated DNA breakage and joining process. Such reactions have a wide range of biological outcomes, from integration and excision of virus genomes into and out of host chromosomes, to acquisition of ...
David Sherratt, Avril Arthur, Paul Dyson
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Mechanisms of Site-Specific Recombination
Annual Review of Biochemistry, 2006Integration, excision, and inversion of defined DNA segments commonly occur through site-specific recombination, a process of DNA breakage and reunion that requires no DNA synthesis or high-energy cofactor. Virtually all identified site-specific recombinases fall into one of just two families, the tyrosine recombinases and the serine recombinases ...
Nigel D F, Grindley +2 more
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THE MECHANISM OF CONSERVATIVE SITE-SPECIFIC RECOMBINATION
Annual Review of Genetics, 1988Cet article de synthese decrit brievement les roles biologiques varies de la recombinaison site-specifique conservative (RSSC) et decrit plus particulierement les proteines et les composantes de l'ADN des systemes RSSC et les mecanismes de ...
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Site-specific recombination by Tn3 resolvase
Trends in Genetics, 1989Site-specific recombination processes in microbes bring about precise DNA rearrangements which have diverse and important biological functions. The sites and recombinase enzymes used for these processes fall into two distinct families. Here we describe how experiments with one family, exemplified by the resolution system of transposon Tn3, have ...
W M, Stark, M R, Boocock, D J, Sherratt
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Site specific radioiodination of recombinant hirudin
Analytical Biochemistry, 1990Recombinant hirudin variant rHV2-Lys47 was radioiodinated using the chloramine-T method. Depending on the reaction pH, the two tyrosine residues, Tyr3 and Tyr63, responded differently to iodination but without change in total iodination yield. Of the incorporated -125 iodine 80% was located on Tyr3 at pH 7.4, but 65% was found on Tyr63 at pH 4.
A, Tuong +3 more
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Site-specific recombination in Zea mays
Theoretical and Applied Genetics, 2005The elimination of marker genes after selection is recommended for the commercial use of genetically modified plants. We compared the applicability of the two site-specific recombination systems Cre/lox and Flp/FRT for marker gene elimination in maize plants.
S, Kerbach, H, Lörz, D, Becker
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