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Site-specific recombination in bacteriophage lambda
Journal of Molecular Biology, 1977Abstract Lambda attB-attP is a derivative of bacteriophage lambda that contains both attB and attP, two sites required for integrative recombination. Lambda attB-attP can undergo int-mediated recombination to yield progeny phages whose DNA is 15% shorter than that of the parental phage.
J, Engler, R B, Inman
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Determinants of directionality in lambda site-specific recombination
Cell, 1984The DNA structural features governing directionality in lambda site-specific recombination are shown to reside in regions of the phage attachment site more than 70 bp to the left and more than 40 bp to the right of the cross-over region. Disposition of these sequences on the same attachment site in integration, and on different attachment sites in ...
W, Bushman, S, Yin, L L, Thio, A, Landy
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Site-specific recombination: developments and applications
Current Opinion in Biotechnology, 1994Site-specific DNA recombination systems have considerable utility in manipulating DNA and can facilitate many cloning and gene transfer techniques. The ability of a number of recombinases to catalyze efficient DNA recombination in higher eukaryotes has important and exciting consequences for precise chromosome and transgene engineering. Exploitation of
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Introduction to site-specific recombination
2005Recombination provides a means for creating genetic variety. Exchange of information within gene pools expands their diversity and enhances the choices available for natural selection to act on. Recombination can be broadly divided into two classes: the highly pervasive “homologous” recombination and the more specialized “site-specific recombination.”
Makkuni Jayaram, Ian Grainge
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2000
Site-specific recombination occurs in the temperate response of bacteriophages, the integration of plasmids, and the movement of transposons. While there are elements of the basic recombination pathways discussed in Chapter 5, there are unique aspects to each of these processes.
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Site-specific recombination occurs in the temperate response of bacteriophages, the integration of plasmids, and the movement of transposons. While there are elements of the basic recombination pathways discussed in Chapter 5, there are unique aspects to each of these processes.
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Site-specific recombination systems in filamentous phages
Molecular Genetics and Genomics, 2012Since the discovery of the integration mechanism of the filamentous phage CTXϕ of Vibrio cholerae, integrating filamentous phages have been discovered to be more abundant and diverse than previously recognized. However, the integration systems of filamentous phages have not been fully investigated.
Ahmed, Askora +2 more
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Engineering the mouse genome by site-specific recombination
Current Opinion in Biotechnology, 1999Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for ...
Metzger, Daniel, Feil, Robert
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