Results 81 to 90 of about 9,966,235 (337)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Causal sites as quantum geometry
, 2004 We propose a structure called a causal site to use as a setting for quantum geometry, replacing the underlying point set. The structure has an interesting categorical form, and a natural "tangent 2-bundle," analogous to the tangent bundle of a smooth ...
Artin M. +5 more
core +3 more sources
THE GOLDEN HORDE ARCHAEOLOGICAL SITES IN THE PENZA REGION (MAPING EXPERIENCE)
Археология евразийских степейThe paper deals with the study of the Golden Horde sites in the Penza region and their mapping – not just the territorial analysis of archaeological sites, using maps, but also their study.
Svetlana A. Kishinskaya
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19 [PDF]
, 2020 Franklin Wang‐Ngai Chow +26 more
openalex +1 more source
A different way to look at things : the development of consultancy in a residential service for children and young people [PDF]
, 2005 The support of consultancy and the tasks associated with consultation are considered to play a vital role in the development of good practice in residential care and in safeguarding children and young people.
Kendrick, Andrew +1 more
core
Should historic sites protection be targeted at the most famous? Evidence from a contingent valuation in Scotland [PDF]
, 2016 We used a contingent valuation survey of a random sample of the general public living in Scotland to estimate how willingness to pay (WTP) for the conservation of historic sites (such as castles and stone circles) varies with how well-known these sites ...
Hanley, Nick +2 more
core +1 more source
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2022 Introdução: Dentre os transtornos alimentares (TAs), têm a anorexia nervosa (AN) e a bulimia nervosa (BN), que através de blogs e sites Pró-Ana e Pró-Mia presentes nas redes sociais, estão sendo vistos como um estilo de vida.
Marília Somaggio Souza +1 more
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source