Results 221 to 230 of about 65,671 (281)

β-Sitosterol activates autophagy to inhibit the development of hepatocellular carcinoma by regulating the complement C5a receptor 1/alpha fetoprotein axis.

European Journal of Pharmacology, 2023
Hepatocellular carcinoma (HCC) is highly refractory. β-Sitosterol has been reported to suppress proliferation and migration as well as interfere with cell metabolism in tumors.
Yuankun Chen, Song Yin, R. Liu, Yijun Yang, Qiuping Wu, Wenyu Lin, Wenting Li   +6 more
semanticscholar   +1 more source

Sitosterol xanthomatosis

Journal of the European Academy of Dermatology and Venereology, 2006
AbstractBackground  Sitosterolaemia is a lipid disorder in which plasma plant sterol levels are extremely elevated. Sitosterolaemia is clinically characterized by tuberous and tendon xanthomas, premature vascular disease and arthritis.Objective  To report a case of sitosterolaemia diagnosed by cutaneous manifestations and to review this rare disease ...
S S S, Guirado, J S, Conejo-Mir, M A, Muñoz, J B, Wite, L R, Fernandez-Freire, J V, Ortíz   +5 more
openaire   +2 more sources

β-sitosterol targets glucocorticoid receptor to reduce airway inflammation and remodeling in allergic asthma.

Pulmonary Pharmacology & Therapeutics, 2022
INTRODUCTION In most asthma patients, symptoms are controlled by treatment with glucocorticoid, but long-term or high-dose use can produce adverse effects. Therefore, it is crucial to find new therapeutic strategies.
Jianfeng Xu, Lei Yang, Tiantian Lin
semanticscholar   +1 more source

β-sitosterol assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line.

Journal of Biomedical Materials Research. Part A, 2020
Cancer nanomedicine is an emerging field of cancer therapeutics. Incidence of hepatocellular carcinoma is increasing worldwide and currently, it is the second leading cause of cancer-related deaths.
Rajendran Raj, Ezhilarasan Devaraj, R. Shanmugam   +2 more
semanticscholar   +1 more source

Purification of sitosterol

Lipids, 1973
AbstractSitosterol and stigmastanol are obtained from the Raney nickel catalyzed hydrogenation of stigmasterol. The sitosterol was separated from stigmastanol by silica gel column chromatography of its dibromide. Sitosterol was also obtained from the steam deodorizer distillate of crude cottonseed oil and purified by manifold recrystallizations of the ...
Henry W. Kircher, Fumiko U. Rosenstein
openaire   +1 more source

In silico and in vivo analysis to identify the antidiabetic activity of beta sitosterol in adipose tissue of high fat diet and sucrose induced type-2 diabetic experimental rats

Toxicology Mechanisms and Methods, 2019
Adipose tissue is the primary site of storage for excess energy as triglyceride and it helps in synthesizing a number of biologically active compounds that regulate metabolic homeostasis.
R. Ponnulakshmi, B. Shyamaladevi, P. Vijayalakshmi, J. Selvaraj   +3 more
semanticscholar   +1 more source

Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives

Organic & Biomolecular Chemistry, 2005
Beta-sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol).
Florence O, McCarthy, Jay, Chopra, Alan, Ford, Sean A, Hogan, Joe P, Kerry, Nora M, O'Brien, Eileen, Ryan, Anita R, Maguire   +7 more
openaire   +2 more sources

β-sitosterol induces reactive oxygen species-mediated apoptosis in human hepatocellular carcinoma cell line

Avicenna Journal of Phytomedicine, 2021
Objective: It is of interest to investigate the anti-proliferative effect of β-sitosterol (BS) on human hepatocellular carcinoma (HepG2) cell line. Materials and Methods: β-sitosterol treatments (0.6 and 1.2 mM/ml) were done in HepG2 and after 24 hr ...
Mary J. Ditty, D. Ezhilarasan
semanticscholar   +1 more source

Are sitosterols atherogenic?

Clinical Pharmacology & Therapeutics, 1962
In the editorial which appeared in the July‐August, 1962, issue of this journal, the untoward effects and possible danger of various cholesterol‐lowering agents were discussed, and only dietary modifications were considered a safe approach. In the discussion of sitosterols, the authors of the editorial stated that no toxic effects had as yet been ...
Bernard Lawn, Oscar W. Portman, Fredrick J. Stare   +2 more
openaire   +1 more source

Sitosterol prevents obesity-related chronic inflammation

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018
The physiological roles of phytosterols in chronic inflammation, which are believed to be involved in the underlying mechanisms for metabolic diseases, have yet to be elucidated. Therefore, in the present study, we aimed to elucidate the physiological roles of phytosterols in both clinical studies and animal experiments.
Makoto, Kurano, Koji, Hasegawa, Motoei, Kunimi, Masumi, Hara, Yutaka, Yatomi, Tamio, Teramoto, Kazuhisa, Tsukamoto   +6 more
openaire   +2 more sources