Results 61 to 70 of about 3,038,180 (280)

MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors

Cell Reports Medicine
Summary: Unlike preceding MERS-related coronaviruses, the recently identified MjHKU4r-CoV-1 strain can directly infect human cells. Nonetheless, its potential pathogenic attributes and underlying molecular mechanisms remain unclear.
Shuai Xia, Fanke Jiao, Jing Chen, Lijue Wang, Tianyu Lu, Qian Wang, Wei Xu, Xinling Wang, Fei Sun, Yun Zhu, Peng Zhou, Shibo Jiang, Lu Lu   +12 more
doaj   +1 more source

Engineered mimetics of the pre-hairpin intermediate and post-fusion six-helix bundle of HIV-1 gp41.

, 2014
(A) Domain organization of HIV-1 gp41 and sequences of the six-helix bundle (6-helix, coreS and coreSP) and pre-hairpin (5-helix and N35CCG-N13) mimetics.
Katheryn Lohith (611896), Annie Aniana (611895), Jane M. Sayer (611897), G. Marius Clore (237616), Carole A. Bewley (237605), Julien Roche (611898), John M. Louis (237589)   +6 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus

Journal of General Virology, 2002
Paramyxoviruses may adopt a similar fusion mechanism to other enveloped viruses, in which an anti-parallel six-helix bundle structure is formed post-fusion in the heptad repeat (HR) regions of the envelope fusion protein. In order to understand the fusion mechanism and identify fusion inhibitors of Newcastle disease virus (NDV), a member of the ...
Ming, Yu, Enxiu, Wang, Youfang, Liu, Dianjun, Cao, Ningyi, Jin, Catherine W-H, Zhang, Mark, Bartlam, Zihe, Rao, Po, Tien, George F, Gao   +9 more
openaire   +2 more sources

CryoET structures of immature HIV Gag reveal a complete six-helix bundle and stabilizing small molecules distinct from IP6 [PDF]

, 2020
Abstract Gag is the major HIV-1 structural polyprotein precursor. The Gag SP1 domain with the last residues of CA have been hypothesized to form a six-helix bundle necessary for particle assembly, but this bundle has not been fully resolved.
Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang   +13 more
openaire   +1 more source

Dimensional control of DNA nanostructures enhances cellular uptake and guides tissue-regenerative responses

Journal of Nanobiotechnology
Precise regulation of cellular functions is fundamental for advancing tissue regeneration and drug delivery systems. Structural DNA nanotechnology enables the design of well-defined nanostructures, emerging as a promising platform in these biomedical ...
Xinyue Tang, Tingting Zhai, Tiancheng Li, Yu Jin, Dantong Lei, Cheng Zhu, Luyao Qu, Yingfu Li, Yudong Wang, Hongzhou Gu, Bing Fang   +10 more
doaj   +1 more source

Six-Helix Bundles Designed from DNA

, 2016
We present a designed cyclic DNA motif that consists of six DNA double helices that are connected to each other at two crossover sites. DNA double helices with 10.5 nucleotide pairs per turn facilitate the programming of DNA double crossover molecules to
Tong Wang (87696), Jens Kopatsch (2686531), Chengde Mao (5315), Nadrian C. Seeman (1501729), Shiping Liao (2686528), Frederick Mathieu (2686525)   +5 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Fab crystallization and preliminary X-ray analysis of NC-1, an anti-HIV-1 antibody that recognizes the six-helix bundle core of gp41 [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2010
NC-1 is a murine monoclonal antibody that specifically recognizes the six-helix bundle core of the human immunodeficiency virus type 1 (HIV-1) gp41. As such, it is a useful tool for probing gp41 conformations in HIV-1 membrane fusion. To establish the structural basis underlying the NC-1 specificity, X-ray crystallography was employed to solve its ...
Lei, Jin, Chungen, Pan, Zhi, Qi, Z Hong, Zhou, Shibo, Jiang   +4 more
openaire   +2 more sources