Results 71 to 80 of about 3,038,180 (280)

Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.

PLoS ONE, 2010
Cerebral cavernous malformations (CCM) are vascular abnormalities of the central nervous system predisposing blood vessels to leakage, leading to hemorrhagic stroke. Three genes, Krit1 (CCM1), OSM (CCM2), and PDCD10 (CCM3) are involved in CCM development.
Christopher F Dibble, Jeremy A Horst, Michael H Malone, Kun Park, Brenda Temple, Holly Cheeseman, Justin R Barbaro, Gary L Johnson, Sompop Bencharit   +8 more
doaj   +1 more source

Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry. [PDF]

PLoS Pathogens, 2010
In the paramyxovirus cell entry process, receptor binding triggers conformational changes in the fusion protein (F) leading to viral and cellular membrane fusion.
Matteo Porotto, Barry Rockx, Christine C Yokoyama, Aparna Talekar, Ilaria Devito, Laura M Palermo, Jie Liu, Riccardo Cortese, Min Lu, Heinz Feldmann, Antonello Pessi, Anne Moscona   +11 more
doaj   +1 more source

A Designed Branched Three-Helix Bundle Protein Dimer

, 2016
The ultimate goals of de novo protein design are the construction of novel tertiary structures and functions. Here is presented the design and synthesis of a uniquely branched three-helix bundle that folds into a well-folded dimeric protein.
Gunnar T. Dolphin (2540101)
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

α-helix bundle mechanical stability.

, 2018
(a) Schematic representation of talin rod bundles and (b) α-catenin domains. Vinculin binding sites colored in blue. (c) Cartoon illustration of R9, where Cα of N-terminal residue colored in blue and Cα of C-terminal residue is red. (d) SMD water box and
Armando del Río Hernández (5147222), Alexander William M. Haining (5147219), Vesa P. Hytönen (7531), Magdaléna von Essen (5147225), Vasyl V. Mykuliak (3270771)   +4 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Signal Transduction and Targeted Therapy, 2021
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback for global economy and health.
Qianqian Zhang, Rong Xiang, Shanshan Huo, Yunjiao Zhou, Shibo Jiang, Qiao Wang, Fei Yu   +6 more
doaj   +1 more source

A designed branched three-helix bundle protein dimer

, 2006
The ultimate goals of de novo protein design are the construction of novel tertiary structures and functions. Here is presented the design and synthesis of a uniquely branched three-helix bundle that folds into a well-folded dimeric protein.
Dolphin, Gunnar,
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source