Results 91 to 100 of about 3,038,180 (280)
Identification of the natural product berberine as an antiviral drug
AMB Express, 2020 Drugs targeting the fusion process of viral entry into host cells have been approved for clinical use in the treatment of AIDS. There remains a great need to improve the use of existing drugs for HIV therapy.
Jiping Shao +4 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein +7 more
wiley +1 more source
HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics
Journal of the Formosan Medical Association, 2010 Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
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Advanced Engineering Materials, EarlyView.This study explores the influences of calendering and surface treatment during direct ink writing (DIW) of thermochromic cholesteric liquid crystal (CLC) on PET nonwovens. For the PVA‐coated nonwovens, calendering reduces pore size leading to reduced ink absorption and enhanced spreading. The NeverWet‐coated nonwovens improve thermochromic responses by
Sreenivasan Sreenivasan Narayanan +3 more
wiley +1 more source
Design of an abiotic unimolecular three-helix bundle
International audienceA unimolecular three-helix bundle aromatic foldamer in which each helix interacts with the two others was designed by stepwise transformation of a parallel trimolecular three-helix ...
Allmendinger, Lars +4 more
core +1 more source
Advances in Sustainable and Wearable Textile Based Soft Robotics
Advanced Functional Materials, EarlyView.This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas +6 more
wiley +1 more source
Oligourea helix bundle binds detergents with diverse polar head groups [PDF]
Detergents bearing diverse polar head groups including ionic, zwitterionic and non-ionic can adaptively bind to an oligourea helix bundle through hydrophobic effect in water.Mimétisme et ingénierie d'enzymes artificielles à l'aide de ...
BURATTO, Jeremie +6 more
core +1 more source
Structure‐Guided Dynamical Mechanics in Bioinspired Double Twisted Laminated Thin Films
Advanced Functional Materials, EarlyView.This work explores a dynamic mechanistic study of crack propagation and puncture testing via real‐time monitoring of crack initiation, propagation, and termination through nature‐inspired single and double twisted architectures fabricated from cellulose nanocrystals.
Justin Brackenridge +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash +4 more
wiley +1 more source
ADS-J21 is a novel HIV-1 entry inhibitor targeting gp41
Current Research in Microbial SciencesHIV-1 envelope glycoprotein gp41 mediates fusion between HIV-1 and host cell membranes, making inhibitors of gp41 attractive anti-HIV drugs. We previously reported an efficient HIV-1 fusion inhibitor, ADS-J1, with a Y-shaped structure.
Ruiying Liang +12 more
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