Results 81 to 90 of about 3,038,180 (280)
The Membrane Proximal External Region of the HIV-1 Envelope Glycoprotein gp41 Contributes to the Stabilization of the Six-Helix Bundle Formed with a Matching N′ Peptide [PDF]
Biochemistry, 2008 The HIV-1 envelope glycoprotein gp41 undergoes a sequence of extensive conformational changes while participating in the fusion of the virus with the host cell. Since the discovery of its postfusion conformation, the structure and function of the protease-resistant six-helix bundle (6-HB) have been the subject of extensive investigation.
Eran, Noah +4 more
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie +8 more
wiley +1 more source
Protein Folding Mechanism of the Dimeric AmphiphysinII/Bin1 N-BAR Domain. [PDF]
PLoS ONE, 2015 The human AmphyphisinII/Bin1 N-BAR domain belongs to the BAR domain superfamily, whose members sense and generate membrane curvatures. The N-BAR domain is a 57 kDa homodimeric protein comprising a six helix bundle.
Tobias Gruber, Jochen Balbach
doaj +1 more source
Helix Notice of Adopted Amendment (2010-08-27)
, 2010 15 pp. Adopted 2010-08-27. Department of Land Conservation and Development Notice of Adopted AmendmentAs required by Federal Emergency Management Agency, the city of Helix updated its floodplain ordinance and adopted new digital floodplain maps in order ...
Helix
core +1 more source
, 2007 Fusion of the viral and cellular membranes is a critical step in the infection of cells by the human T-cell leukemia virus type 1 (HTLV-1) and this process is catalysed by the viral envelope glycoproteins.
Brighty, David W. +9 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera +20 more
wiley +1 more source
The Potent Human Immunodeficiency Virus Type 1 (HIV-1) Entry Inhibitor HR212 Blocks Formation of the Envelope Glycoprotein gp41 Six-Helix Bundle [PDF]
AIDS Research and Human Retroviruses, 2013 HR212, a recombinant protein composed of the heptad repeat, is a rationally designed human immunodeficiency virus type 1 (HIV-1) fusion inhibitor. This protein can be easily produced by Escherichia coli at a low cost.
Wenjie, Ouyang +4 more
openaire +2 more sources
Computer-Aided Approaches for Targeting HIVgp41
Biology, 2012 Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV) delivers its genetic material into the human T-cell host. Fusion is mediated in large part by the viral glycoprotein 41 (gp41) which advances through four distinct ...
William J. Allen, Robert C. Rizzo
doaj +1 more source
, 2016 A comparative study on the folding of multiple three-α-helix bundle proteins including α3D, α3W, and the B domain of protein A (BdpA) is presented. The use of integrated-tempering-sampling molecular dynamics simulations achieves reversible folding and ...
Qiang Shao (112168)
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate automatic magnetic resonance imaging (MRI)‐derived lesion morphometrics against manual measurements and their prognostic value for characterizing distinct acute to chronic neurological recovery trajectories after spinal cord injury (SCI). Methods We studied a retrospective, multicenter cohort of cervical and thoracolumbar
Dario Pfyffer +28 more
wiley +1 more source