HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses [PDF]
Skeletal Muscle, 2018 Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy.
Eva Pigna +7 more
doaj +3 more sources
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering [PDF]
, 2018 Summary: Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including ...
Cappellari, O +21 more
core +8 more sources
Skeletal muscle ultrasound [PDF]
Neurological Research, 2011 Muscle ultrasound is a convenient technique to visualize normal and pathological muscle tissue as it is non-invasive and real-time. Neuromuscular disorders give rise to structural muscle changes that can be visualized with ultrasound: atrophy can be objectified by measuring muscle thickness, while infiltration of fat and fibrous tissue increases muscle
Pillen, S., Alfen, N. van
openaire +4 more sources
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy
Cells, 2020 Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, P. Delafontaine
semanticscholar +1 more source
Meeting report: the 2021 FSHD International Research Congress
Skeletal Muscle, 2022 Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progressing and highly heterogeneous muscle wasting with a typical onset in the late teens/early adulthood [1]. Although the etiology of the
Sujatha Jagannathan +9 more
doaj +1 more source
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake.
Comprehensive Physiology, 2020 The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of glucose homeostasis, responsible for 80% of postprandial glucose uptake from the circulation.
Karla E. Merz, D. Thurmond
semanticscholar +1 more source
Prions in skeletal muscle [PDF]
Proceedings of the National Academy of Sciences, 2002 Considerable evidence argues that consumption of beef products from cattle infected with bovine spongiform encephalopathy (BSE) prions causes new variant Creutzfeldt–Jakob disease. In an effort to prevent new variant Creutzfeldt–Jakob disease, certain “specified offals,” including neural and lymphatic tissues, thought to contain high ...
BOSQUE PJ +6 more
openaire +2 more sources
Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression [PDF]
, 2012 Skeletal muscle derived stem cells (MDSCs) transplanted into injured myocardium can differentiate into fast skeletal muscle specific myosin heavy chain (sk-fMHC) and cardiac specific troponin-I (cTn-I) positive cells sustaining recipient myocardial ...
A Du +39 more
core +7 more sources
Denervation does not induce muscle atrophy through oxidative stress [PDF]
, 2017 Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness.
Adamo, Sergio +10 more
core +2 more sources
Single-cell transcriptional profiles in human skeletal muscle
Scientific Reports, 2020 Skeletal muscle is a heterogeneous tissue comprised of muscle fiber and mononuclear cell types that, in addition to movement, influences immunity, metabolism and cognition.
A. Rubenstein +12 more
semanticscholar +1 more source