Results 211 to 220 of about 68,097 (255)
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Glucocorticoid-induced skeletal muscle atrophy
The International Journal of Biochemistry & Cell Biology, 2013Many pathological states characterized by muscle atrophy (e.g., sepsis, cachexia, starvation, metabolic acidosis and severe insulinopenia) are associated with an increase in circulating glucocorticoids (GC) levels, suggesting that GC could trigger the muscle atrophy observed in these conditions. GC-induced muscle atrophy is characterized by fast-twitch,
O, Schakman +4 more
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Disuse Atrophy of Human Skeletal Muscles
Archives of Neurology, 1969DISUSE ATROPHY is a term frequently and glibly used by clinicians and pathologists alike when faced with a nonspecific muscular atrophy. Unfortunately for both, this is usually a diagnosis of exclusion. Histological changes in cases of pure disuse atrophy in human skeletal muscles are wanting.
A N, Patel, Z A, Razzak, D K, Dastur
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Role of ATF4 in skeletal muscle atrophy
Current Opinion in Clinical Nutrition & Metabolic Care, 2017Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams +2 more
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Lysosomes and disuse atrophy of skeletal muscle
Archives of Biochemistry and Biophysics, 1971The specific activities of the acid hydrolases β-glucosidase, β-galactosidase, β-N-acetylhexosaminidase, arylsulfatase, and acid phosphatase have been measured during the time course of disuse atrophy of rat gastrocnemius muscles. These enzymes are considered to be lysosomal in origin.
S R, Max, R F, Mayer, L, Vogelsang
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Skeletal Muscle Atrophy in Bioengineered Skeletal Muscle: A New Model System
Tissue Engineering Part A, 2013Skeletal muscle atrophy has been well characterized in various animal models, and while certain pathways that lead to disuse atrophy and its associated functional deficits have been well studied, available drugs to counteract these deficiencies are limited.
Peter H U, Lee, Herman H, Vandenburgh
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JAMA: The Journal of the American Medical Association, 1942
Mammalian skeletal muscle is served by a number of different types of nerve fibers. Some represent the central and others the autonomic nervous system. Diagrammatic representation of the component parts of skeletal muscle innervation has been attempted in figure 1.
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Mammalian skeletal muscle is served by a number of different types of nerve fibers. Some represent the central and others the autonomic nervous system. Diagrammatic representation of the component parts of skeletal muscle innervation has been attempted in figure 1.
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Oxidative stress: Roles in skeletal muscle atrophy
Biochemical Pharmacology, 2023Oxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and increased proteolysis are all critical factors in the process of muscle atrophy. In particular, oxidative stress is the key factor that triggers skeletal muscle atrophy. It is activated in the early stages of muscle atrophy and can be regulated by various factors.
Han, Zhang +11 more
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A Study of Disuse Atrophy of Skeletal Muscle in the Rabbit
The Journal of Bone & Joint Surgery, 19571. There is a fundamental difference in the reaction to immobilization of the tibialis anterior and the gastroenemius its the rabbit. 2. There is an increased blood flow in both atrophy and hypertrophy of skeletal muscle in this animal. 3. Atrophy and hypertrophy appear to represent a change in intracellular cotsstituents without change in the water ...
A B, FERGUSON, L, VAUGHAN, L, WARD
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Progressive Atrophy of Skeletal Muscles
Postgraduate Medicine, 1967The “motor unit” concept is delineated and a classification of atrophies is presented. The four main categories are composed of disease states associated with (1) proximal symmetric, (2) distal symmetric, (3) diffuse bilateral and (4) restricted atrophies of skeletal muscles.
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2017
Skeletal muscle atrophy occurs when there is a higher concentration of the transcription factor Forkhead box protein O1 (Foxo-1) inside the nucleus of a skeletal muscle cell than in the cytoplasm. Within a skeletal muscle cell, only dephosphorylated Foxo-1 can enter the nucleus, while only phosphorylated Foxo-1 can exit the nucleus.
Furman, Samantha +2 more
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Skeletal muscle atrophy occurs when there is a higher concentration of the transcription factor Forkhead box protein O1 (Foxo-1) inside the nucleus of a skeletal muscle cell than in the cytoplasm. Within a skeletal muscle cell, only dephosphorylated Foxo-1 can enter the nucleus, while only phosphorylated Foxo-1 can exit the nucleus.
Furman, Samantha +2 more
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