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Human umbilical cord-derived mesenchymal stromal cell exosomes ameliorate aging-associated skeletal muscle atrophy and dysfunction in SAMP10 mice. [PDF]

Stem Cell Res Ther
Huang Z, Piao L, Meng X, Inoue A, Hitomi K, Umegaki H, Kuzuya M, Cheng XW.   +7 more
europepmc   +1 more source

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Oxidative stress: roles in skeletal muscle atrophy.

Biochemical Pharmacology, 2023
Oxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and increased proteolysis are all critical factors in the process of muscle atrophy.
Han Zhang, Guangdong Qi, Kexin Wang, Jiawen Yang, Yuntian Shen, Xiaoming Yang, Xin Chen, Xinlei Yao, Xiaosong Gu, Lei Qi, Chunchen Zhou, Hualin Sun   +11 more
semanticscholar   +3 more sources

Factors mediating spaceflight-induced skeletal muscle atrophy.

American Journal of Physiology-Cell Physiology, 2022
Skeletal muscle atrophy is a well-known consequence of spaceflight. Because of the potential significant impact of muscle atrophy and muscle dysfunction on astronauts and to their mission, a thorough understanding of the mechanisms of this atrophy and ...
P. H. Lee, Michael Chung, Zhanping Ren, Devin B Mair, Deok-Ho Kim   +4 more
semanticscholar   +3 more sources

Skeletal Muscle Atrophy

Encyclopedia of Behavioral Medicine, 2020

semanticscholar   +2 more sources

Mitochondrial Dysfunction and Skeletal Muscle Atrophy: Causes, Mechanisms, and Treatment Strategies.

Mitochondrion (Amsterdam. Print), 2023
Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the most dynamic and plastic tissues in the human body and plays a vital role in movement, posture and force production.
Gökhan Burçin Kubat, Esmaa Bouhamida, Oner Ulger, Ibrahim Turkel, G. Pedriali, D. Ramaccini, O. Ekinci, Berkay Ozerklig, O. Atalay, S. Patergnani, Beyza Nur Sahin, G. Morciano, M. Tuncer, E. Tremoli, P. Pinton   +14 more
semanticscholar   +1 more source

Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling.

American Journal of Physiology. Endocrinology and Metabolism, 2023
Skeletal muscle atrophy is often found in patients with type 2 diabetes mellitus (T2DM) which is characterized with insulin resistance. As the largest tissue in the body, skeletal muscle plays important roles in insulin resistance. Advanced glycation end
Haixia Du, Yan-Li Ma, Xiqiang Wang, Yong Zhang, Ling Zhu, S. Shi, S. Pan, Zhongwei Liu   +7 more
semanticscholar   +1 more source

Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction.

American Journal of Physiology - Cell Physiology, 2021
OBJECTIVES Myocardial infarction (MI)-induced heart failure (HF) is commonly accompanied with profound effects on skeletal muscle. With the process of MI-induced HF, perturbations in skeletal muscle contribute to muscle atrophy.
Lili Feng, Bo-wen Li, Xing Yue, Zhen-Jun Tian, Mengxin Cai   +4 more
semanticscholar   +1 more source

Mechanisms of skeletal muscle atrophy

Current Opinion in Rheumatology, 2006
Recent clinical and mechanistic studies have shown that increased proteolysis is a major determinant of muscle wasting in numerous catabolic states and of alterations in myopathies or dystrophies. The implications of these observations for improving muscle mass and function are discussed.Several proteolytic systems (i.e. the ubiquitin-proteasome system,
Ventadour, Sophie, Attaix, Didier
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Glucocorticoid-induced skeletal muscle atrophy

The International Journal of Biochemistry & Cell Biology, 2013
Many pathological states characterized by muscle atrophy (e.g., sepsis, cachexia, starvation, metabolic acidosis and severe insulinopenia) are associated with an increase in circulating glucocorticoids (GC) levels, suggesting that GC could trigger the muscle atrophy observed in these conditions. GC-induced muscle atrophy is characterized by fast-twitch,
O, Schakman, S, Kalista, C, Barbé, A, Loumaye, J P, Thissen   +4 more
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Mitochondrial-apoptotic signaling involvement in remodeling during myogenesis and skeletal muscle atrophy.

Seminars in Cell and Developmental Biology, 2022
Mitochondria play a major role in apoptotic signaling. In addition to its role in eliminating dysfunctional cells, mitochondrial apoptotic signaling is implicated as a key component of myogenic differentiation and skeletal muscle atrophy.
Fasih Ahmad Rahman, J. Quadrilatero
semanticscholar   +1 more source