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Isolation, characterization, and molecular regulation of muscle stem cells
keletal muscle has great regenerative capacity which is dependent on muscle stem cells, also known as satellite cells. A loss of satellite cells and/or their function impairs skeletal muscle regeneration and leads to a loss of skeletal muscle power ...
So-ichiro eFukada +5 more
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Skeletal muscle satellite cell transplantation [PDF]
Cell transplantation is currently gaining a growing interest as a potential new means of improving the prognosis of patients with cardiac failure. The basic assumption is that left ventricular dysfunction is primarily caused by the loss of a critical number of cardiomyocytes and that their replacement by new contractile cells could functionally ...
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Contribution of stem cells to skeletal muscle regeneration.
Stem cells for skeletal muscle originate from dermomyotome of the embryo. The early marker of these cells is expression of both transcription factors Pax3 and Pax7 (Pax3+/Pax7+ cells).
Jerzy Moraczewski +8 more
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Following skeletal muscle injury, muscle stem cells (satellite cells) are activated, proliferate, and differentiate to form myofibers. We show that mRNA-decay protein AUF1 regulates satellite cell function through targeted degradation of specific mRNAs ...
Devon M. Chenette +6 more
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Satellite cell proliferation and skeletal muscle hypertrophy [PDF]
Satellite cells are small, mononuclear cells found in close association with striated skeletal muscles cells (myofibers). These cells appear to function as reserve myoblasts. A critical role for these cells in the process of muscle regeneration following injury has been clearly established.
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Molecular Regulation and Rejuvenation of Muscle Stem (Satellite) Cell Aging
BACKGROUND: Age-related muscle loss leads to lack of muscle strength, resulting in reduced posture and mobility and an increased risk of falls, all of which contribute to a decrease in quality of life.
Anna Meiliana +2 more
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The Many Roles of Macrophages in Skeletal Muscle Injury and Repair
Skeletal muscle is essential to physical activity and energy metabolism. Maintaining intact functions of skeletal muscle is crucial to health and wellbeing.
Xingyu Wang, Lan Zhou
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HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
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The Skeletal Muscle Satellite Cell [PDF]
The skeletal muscle satellite cell was first described and named based on its anatomic location between the myofiber plasma and basement membranes. In 1961, two independent studies by Alexander Mauro and Bernard Katz provided the first electron microscopic descriptions of satellite cells in frog and rat muscles.
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Functional Overload Enhances Satellite Cell Properties in Skeletal Muscle
Skeletal muscle represents a plentiful and accessible source of adult stem cells. Skeletal-muscle-derived stem cells, termed satellite cells, play essential roles in postnatal growth, maintenance, repair, and regeneration of skeletal muscle.
Shin Fujimaki +5 more
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