Results 211 to 220 of about 193,078 (253)

Impact of denosumab on skeletal-related events in solid tumors.

Journal of Clinical Oncology, 2018
e18754Background: Skeletal-related events (SRE) are frequent consequences of bone metastases from solid tumours like breast, prostate and lung.
Sridevi Rajeeve, Stuthi Perimbeti, Karan Jatwani, Rishi Shrivastav, Vivek Modi   +4 more
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Impact of skeletal-related events on multiple myeloma treatment.

Journal of Clinical Oncology, 2018
e20009Background: Skeletal-related events (SREs), sequelae of bone lesions, are common and devastating complications in patients with multiple myeloma (MM).This study assessed the impact of SREs on...
Debajyoti Bhowmik, Nianwen Shi, Janna Manjelievskaia, Xue Song, Sarah Vidito, Michele Intorcia   +5 more
openaire   +1 more source

Management of skeletal-related events and fracture prevention in systemic mastocytosis

Osteoporosis International
Systemic mastocytosis is a rare condition caused by the accumulation of abnormal mast cells (MC) in various organs, including the bone. The diagnosis of mastocytosis is sometimes challenging because of the incidence rate, the heterogeneity of clinical manifestations, and the varying sensitivity of diagnostic tools.
Emily M. Lunn, Steven Lacount, Loren Wissner Greene, Kamyar Asadipooya   +3 more
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Skeletal-Related Events In Myeloma: A Population-Based Study

Blood, 2013
Abstract Introduction New therapies have resulted in improvements in myeloma survival, with increasing numbers of patients receiving treatment over several years. Despite this progress, the remitting and relapsing course of the disease continues to be associated with increases in patient morbidity and
John Ashcroft, Bagguley Timothy, Alexandra Smith, Han-I Wang, Debra Howell, Hazem A Sayala, Gordon Cook, Andrew Jack, Russell Patmore, Eve Roman   +9 more
openaire   +1 more source

Analysis of skeletal-related events in breast cancer and response to therapy

Seminars in Oncology, 2001
The skeleton is a common site for the spread of metastatic cancer and skeletal complications are a cause of significant morbidity and mortality. Treatment of skeletal morbidity is therefore an essential component of therapy for cancer patients with bone metastases. Bisphosphonates are currently the treatment of choice for skeletal complications.
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The burden of skeletal-related events in patients with prostate cancer and bone metastasis

Urologic Oncology: Seminars and Original Investigations, 2015
To assess contemporary characteristics, hospital admissions, charges, and mortality in patients with prostate cancer (CaP) who have bone metastases and skeletal-related events in an observational study.Relying on the Nationwide Inpatient Sample (NIS), patients with CaP with bone metastases between 1998 and 2010 were abstracted. Patients who experienced
Florian, Roghmann, Carina, Antczak, Rana R, McKay, Toni, Choueiri, Jim C, Hu, Adam S, Kibel, Simon P, Kim, Keith J, Kowalczyk, Mani, Menon, Paul L, Nguyen, Fred, Saad, Jesse D, Sammon, Marianne, Schmid, Shyam, Sukumar, Maxine, Sun, Joachim, Noldus, Quoc-Dien, Trinh   +16 more
openaire   +2 more sources

Prevention of Skeletal-Related Events With Extended-Interval Denosumab: A Review of the Literature

Annals of Pharmacotherapy, 2023
Objective: To review published clinical trial data related to efficacy and safety of administering denosumab at extended dosing intervals for prevention of skeletal-related events (SREs) in cancer patients. Data Sources: A literature ...
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VPA-related axial skeletal defects and apoptosis: A proposed event cascade

Reproductive Toxicology, 2010
VPA axial malformations are related to embryonic somitic histone hyperacetylation. In cancer, histone hyperacetylation activates apoptosis. To verify if apoptosis is involved in somitic abnormalities, VPA-exposed embryos were evaluated for DNA fragmentation and for pro- (p53, acetylated p53, caspase 3) and anti-apoptotic (Sirt 1) protein expression ...
Francesca, Di Renzo, Maria Luisa, Broccia, Erminio, Giavini, Elena, Menegola   +3 more
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Patients with SMARCA4-deficient thoracic sarcoma and severe skeletal-related events

Lung Cancer, 2019
SMARCA4-deficient thoracic sarcoma(DTS) is a recently identified new entity of thoracic malignancies characterized by inactivation of SMARCA4. Patients with SMARCA4-DTS have a particulary aggresive clinical course and no effective treatments. However, the detailed clinical features of SMARCA4-DTS remain unclear. Here, we report the clinical courses and
Kei Kunimasa, Harumi Nakamura, Kazuko Sakai, Motohiro Tamiya, Madoka Kimura, Takako Inoue, Kazumi Nishino, Hanako Kuhara, Shin-ichi Nakatsuka, Kazuto Nishio, Fumio Imamura, Toru Kumagai   +11 more
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[Predictive factors for skeletal-related events in lung cancer].

Revue des maladies respiratoires, 2020
Skeletal-related events (SRE) are common in patients with bone metastatic lung cancer and have a negative impact on quality of life and survival. The objective of this study is to identify predictive factors for SRE occurrence among this population.We conducted a 3-year retrospective study including 100 lung cancer patients with bone metastasis.Eighty ...
A, Villemain, B, Ribeiro Baptista, N, Paillot, M, Soudant, O, Menard, Y, Martinet, A, Tiotiu   +6 more
openaire   +1 more source