Results 31 to 40 of about 1,365 (145)

N-benzyl-N-methyldecane-1-amine derived from garlic ameliorates UVB-induced photoaging in HaCaT cells and SKH-1 hairless mice [PDF]

Scientific Reports
Skin tissue is susceptible to oxidative stress-induced senescence provoked by ultraviolet (UV) exposure in our daily lives, resulting in photoaging. Herein, we explore whether N-benzyl-N-methyldecan-1-amine (BMDA) derived from garlic ameliorates UVB ...
Phatcharaporn Budluang, Ji Eun Kim, Eun Seo Park, Ayun Seol, Hee Jeong Jang, Moon Sung Kang, Yeon Ha Kim, Jongdoo Choi, Seonghye Kim, Suhkmann Kim, Minseob Koh, Ho Young Kang, Bae-Hwan Kim, Dong-Wook Han, Dae Youn Hwang, Young-Hwa Chung   +15 more
doaj   +2 more sources

Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice [PDF]

Experimental and Toxicologic Pathology, 2014
Sulfur mustard (SM) is a vesicant warfare agent which causes severe skin injuries. Currently, we lack effective antidotes against SM-induced skin injuries, in part due to lack of appropriate animal model(s) that can be used for efficacy studies in laboratory settings to identify effective therapies.
Neera Tewari-Singh, David Orlický, Carl White   +2 more
exaly   +3 more sources

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice [PDF]

Molecules, 2020
Positive physiological benefits of several plant oils on the UV-induced photoaging have been reported in some cell lines and model mice, but perilla oil collected from the seeds of Perilla frutescens L. has not been investigated in this context. To study
Hyeon Jun Choi, Bo Ram Song, Ji Eun Kim, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Hee Seob Lee, Chung Yeoul Lee, Bae-Hwan Kim, Dae Youn Hwang   +10 more
doaj   +2 more sources

Dietary Supplementation with <i>Chrysanthemum morifolium</i> Ramat cv. 'Hangju' Flower Extract Alleviates Skin Photoaging in SKH-1 Hairless Mice. [PDF]

Nutrients
Background/Objectives: Skin photoaging represents a predominant form of extrinsic aging, characterized by structural and functional impairment of the skin barrier. In severe cases, it may precipitate dermatological diseases and even tumors. Given the prevalence and detrimental effects of skin photoaging, strategies for its effective prevention and ...
Lao Y, Geng R, Li M, Kang SG, Huang K, Deng B, Zhou H, Luo R, Tong T.   +8 more
europepmc   +3 more sources

Actinidia chinensis Planch Ameliorates Photoaging in UVB-Irradiated NIH-3T3 Cells and SKH-1 Hairless Mice by Controlling the Reactive Oxygen Species/AKT Pathway [PDF]

Antioxidants
In this study, we evaluated the antiphotoaging properties of Actinidia chinensis Planch (ACP) and the molecular mechanisms underlying its ability to prevent UVB-mediated photoaging.
Jong-Min Jung, Seo-Young Kim, Oh-Yun Kwon, Seung-Ho Lee   +3 more
doaj   +2 more sources

The role of constitutive nitric-oxide synthase in regulation of IKKα after ultraviolet irradiation. [PDF]

Photochem Photobiol
cNOS enhances IKKα expression following UVB exposure by promoting promoter activation, transcriptional elongation, and Ets‐1 stabilization. These actions sustain IKKα levels, reduce UV‐induced skin carcinogenesis, and highlight cNOS as a key protective factor against solar UV damage.
Zhou Y, Tong L, Bastidas B, Liu T, Wright M, Zhou M, Wu S.   +6 more
europepmc   +2 more sources

β-Nicotinamide Mononucleotide Enhances Skin Barrier Function and Attenuates UV-B-Induced Photoaging in Mice [PDF]

Antioxidants
Ultraviolet B (UV-B) radiation significantly contributes to skin photoaging, which is characterized by epidermal thickening, collagen degradation, wrinkle formation, barrier dysfunction, and oxidative stress.
Sung Jin Kim, Sullim Lee, Yea Jung Choi, Minseo Kang, Junghwan Lee, Gwi Seo Hwang, Seok-Seon Roh, Mu Hyun Jin, Sangki Park, Minji Park, Ho Song Cho, Ki Sung Kang   +11 more
doaj   +2 more sources

Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice. [PDF]

Photochem Photobiol, 2015
AbstractSolar ultraviolet B (UVB) radiation has been shown to induce inflammation, DNA damage, p53 mutations and alterations in signaling pathways eventually leading to skin cancer. In this study, we investigated whether fisetin reduces inflammatory responses and modulates PI3K/AKT/NFκB cell survival signaling pathways in UVB‐exposed SKH‐1 hairless ...
Pal HC, Athar M, Elmets CA, Afaq F.
europepmc   +4 more sources

Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice. [PDF]

Photochem Photobiol
Proposed model for the dual role of cNOS in DNA damage and repair upon UV radiation. Abstract Solar ultraviolet (sUV) radiation is a major environmental factor that induces DNA damage, promoting skin aging and carcinogenesis. The formation of cyclobutane pyrimidine dimers (CPDs) is one of the most prevalent forms of UV‐induced DNA lesions, playing a ...
Bahamondes Lorca V, Zhou Y, Athans C, Payne H, Wright M, Feyyaz Z, Tong L, Sammons DL, Wu S.   +8 more
europepmc   +2 more sources

Multi-Omics Analysis Reveals Photodynamic Therapy Ameliorating Skin Photoaging by Improving Cellular Senescence Through Mitohormesis-Mediated Reduction of Citrate Content. [PDF]

Aging Cell
Ultraviolet‐induced skin photoaging involves cellular senescence. Low‐dose photodynamic therapy (PDT) counteracts this by triggering mitochondrial ROS and mitohormesis, which improve metabolism and ameliorate senescence, leading to reduced wrinkles and enhanced skin barrier.
Yan Y, Chang Q, Wu Y, Zhao Y, Yan G, Cao Z, Zhang H, Wang X, Zeng Q, Wang P.   +9 more
europepmc   +2 more sources