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In Vivo Model of Short-Term Efficacy and Favorable Safety of Botulinum Toxin Type E Compared with Type A [PDF]
ToxinsBotulinum toxin suppresses neurotransmitter release, thereby inhibiting muscle contraction and inducing flaccid paralysis. Botulinum toxin type A (BoNT/A) is widely used for neuromuscular blockade but, upon repeated administration, may cause long-lasting
Jeong-Sun Nam +7 more
doaj +2 more sources
Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. [PDF]
Cancer Prev Res (Phila), 2014 Abstract Estrogen receptors (ER), including ER-α and ER-β, are known to regulate multiple biologic responses in various cell types. The expression of ER-β is lost in various cancers. ER-β agonists were shown to modulate inflammation, cancer cell proliferation, and differentiation.
Chaudhary SC +10 more
europepmc +4 more sources
Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling. [PDF]
PLoS ONE, 2012 In order to model squamous cell carcinoma development in vivo, researchers have long preferred hairless mouse models such as SKH-1 mice that have traditionally been classified as 'wild-type' mice irrespective of the genetic factors underlying their ...
Hyunmi Kim +7 more
doaj +1 more source
Redox Biology, 2021 Hypochlorous acid (HOCl) is the active oxidizing principle underlying drinking water disinfection, also delivered by numerous skin disinfectants and released by standard swimming pool chemicals used on a global scale, a topic of particular relevance in ...
Jana Jandova +5 more
doaj +1 more source
Transfersome Encapsulated with the R-carvedilol Enantiomer for Skin Cancer Chemoprevention
Nanomaterials, 2023 The R-carvedilol enantiomer, present in the racemic mixture of the chiral drug carvedilol, does not bind to the β-adrenergic receptors, but exhibits skin cancer preventive activity. For skin delivery, R-carvedilol-loaded transfersomes were prepared using
Md Abdullah Shamim +12 more
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Shiyan dongwu yu bijiao yixue, 2023 Objective To analyze the modeling elements and subjects of the animal model of skin photoaging, and to provide a reference for the preparation and improvement of the model and a basis for the scientific evaluation of the subject.
DENG Yasheng +7 more
doaj +1 more source
Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. [PDF]
PLoS ONE, 2017 Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown.
Hui-Wen Chiu +3 more
doaj +1 more source
Antioxidants, 2022 7-O-methylluteolin (7-ML) is a flavonoid isolated from the aerial parts of Wikstroemia ganpi (W. ganpi). We describe the anti–atopic dermatitis (AD) effects of 7-ML in tert-butyl hydroperoxide (tBHP)-induced HepG2 cells and 2,4-dinitrochlorobenzene (DNCB)
Tae-Young Kim +6 more
doaj +1 more source
Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice. [PDF]
PLoS ONE, 2014 To identify effective therapies against sulfur mustard (SM)-induced skin injuries, various animals have been used to assess the cutaneous pathology and related histopathological changes of SM injuries.
Neera Tewari-Singh +4 more
doaj +1 more source
Marine Drugs, 2021 Echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone) has been known to exhibit anti-oxidative and anti-inflammatory effects. However, no study has been carried out on the efficacy of Ech A against skin photoaging; this process is ...
Jung Eun Seol +10 more
doaj +1 more source