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Skin aging is an intricate physiological process governed by intrinsic and extrinsic factors. Increasing life expectancy has turned skin aging into a growing concern for the general population. Clinical examination of the skin does not fully describe the
Mihai Lupu+4 more
doaj +1 more source
Structural Changes in Aging Human Skin [PDF]
In both exposed and protected areas of progressively older people the underside of the epidermis becomes increasingly flattened out. This flattening is accompanied by a comparable rarefaction of the superficial blood vessels.
Carlisle, Kay, Montagna, William
core +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza+3 more
wiley +1 more source
An invariant-based damage model for human and animal skins [PDF]
Constitutive modelling of skins that account for damage effects is important to provide insight for various clinical applications, such as skin trauma and injury, artificial skin design, skin aging, disease diagnosis, surgery, as well as comparative ...
Li, Wenguang, Luo, Xiaoyu Y.
core +1 more source
Understanding and measuring mechanical signals in the tumor stroma
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz+3 more
wiley +1 more source
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa+13 more
wiley +1 more source
Network-based analysis identifies key regulatory transcription factors involved in skin aging
Skin aging is a complex process involving intricate genetic and environmental factors. In this study, we performed a comprehensive analysis of the transcriptional regulatory landscape of skin aging in canines. Weighted Gene Co-expression Network Analysis
Xiao-Ming Wang+17 more
doaj
Objective Several skin aging assessment scales exist but no standard scale is widely used. Dermatologists may be the most appropriate persons for skin assessment but their perceptions regarding the signs of skin aging are unexplored.
Punnapath Buranasirin+2 more
doaj +1 more source
Біофізичний метод кількісної оцінки інволюційних змін шкіри обличчя [PDF]
Представлена методика определения гормонозависимого старения кожи лица у женщин на основе анализа спектральных различий поляризованной флуоресценции микрочастиц кожи лица в отпечатке на адгезивной пленке.
Галникіна, С.О.
core
Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles. [PDF]
ObjectiveAlmonds are a rich source of fatty acids and antioxidants, and their supplementation is known to significantly modulate serum lipids. The effects of almond on the skin's lipid barrier and the appearance of wrinkles have not yet been elucidated ...
Burney, Waqas A+7 more
core +1 more source