Long and very long lamellar phases in model stratum corneum lipid membranes
Journal of Lipid Research, 2019 Membrane models of the stratum corneum (SC) lipid barrier, either healthy or affected by recessive X-linked ichthyosis, constructed from ceramide [Cer; nonhydroxyacyl sphingosine N-tetracosanoyl-d-erythro-sphingosine (CerNS24) alone or with omega-O ...
Petra Pullmannová +7 more
doaj +1 more source
Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis
International Journal of Molecular Sciences, 2020 Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is ...
Gabsik Yang +5 more
semanticscholar +1 more source
Lipid-Based Nanosystems as a Tool to Overcome Skin Barrier
International Journal of Molecular Sciences, 2021 Skin may be affected by many disorders that can be treated by topical applications of drugs on the action site. With the advent of nanotechnologies, new efficient delivery systems have been developed.
Maddalena Sguizzato +2 more
semanticscholar +1 more source
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes [PDF]
, 2020 Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Ben-Yehuda Greenwald, Maya +9 more
core +2 more sources
By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans. [PDF]
, 2019 Pigmentation evolved in ancestral humans to protect against toxic, ultraviolet B irradiation, but the question remains: "what is being protected?" Because humans with dark pigmentation display a suite of superior epidermal functions in comparison with ...
Abuabara, Katrina +7 more
core +1 more source
The Epidermal Barrier Structure and Function of Re-Harvested Skin from Non-Scalp Donor Sites
Journal of Investigative Surgery, 2023 Aim The aim of this study was to explore the epidermal barrier structure and function of re-harvested skin from non-scalp donor sites. Methods Six patients with large-area deep burns who met the inclusion and exclusion criteria were subjected to split ...
Bohan Zhang +10 more
doaj +1 more source
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development [PDF]
, 2009 Acquisition of epidermal barrier function occurs late in mouse gestation. Several days before birth a wave of barrier acquisition sweeps across murine fetal skin, converging on dorsal and ventral midlines.
Byrne, C +3 more
core +2 more sources
Skin Microbiome Composition and Key Factors of its Barrier Function
Вопросы современной педиатрии, 2023 The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection.
Nikolay N. Murashkin +7 more
doaj +1 more source
bioRxiv, 2020 The epidermis forms a barrier that defends the body from desiccation and entry of harmful substances, while sensing and integrating environmental signals. The tightly orchestrated cellular changes required for the proper formation and maintenance of this
A. Uberoi +18 more
semanticscholar +1 more source
Molecular organization and in situ assembly of the human skin barrier [PDF]
, 2016 A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease.
Hollander, Lianne den
core +1 more source