Results 61 to 70 of about 598,588 (305)

A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids

Scientific Reports, 2021
Excess glucocorticoids (GCs) with either endogenous or exogenous origins deteriorate skin barrier function. GCs bind to mineralocorticoid and GC receptors (MRs and GRs) in normal human epidermal keratinocytes (NHEKs).
Hanil Lee, Eun-Jeong Choi, Eun Jung Kim, Eui Dong Son, Hyoung-June Kim, Won-Seok Park, Young-Gyu Kang, Kyong-Oh Shin, Kyungho Park, Jin-Chul Kim, Su-Nam Kim, Eung Ho Choi   +11 more
doaj   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Reduced humidity induces skin barrier dysfunction and secretion of dipeptidyl peptidase-4 (DPP-4) in a skin-equivalent model [PDF]

Archives of Biological Sciences, 2019
Seasonal changes can affect the physiological condition of the skin and cause various cutaneous disorders. The skin barrier function tends to worsen during winter when humidity is lower compared to other seasons.
Lee Sung Hoon, Bae Il-Hong, Marinho Paulo A., Lee Chang Seok, Lee Jongsung   +4 more
doaj   +1 more source

An in vivo comparative study on ageing skin: bio-mimetic versus traditional approach to skin moisturisation [PDF]

, 2014
Skin dryness is a common condition in elderly individuals. The two main mechanisms to cosmetically alleviate this state rely on the effects of humectants and occlusive substances, mostly in combination.
Grant-Ross, Peter, Kurimo, Ritva, Tamburic, Slobodanka, Todorova, Petya   +3 more
core  

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation [PDF]

, 2012
ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and ...
Blobel, C.P., Bruckner-Tuderman, L., Cobzaru, C., Franzke, C.W., Horiuchi, K., Kurz, T., Loffek, S., Rooijen, N. van, Threadgill, D.W., Triantafyllopoulou, A.   +9 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum

Acta Dermato-Venereologica, 2018
Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less dense ...
Tineke Berkers, Dani Visscher, Gert S. Gooris, Joke A. Bouwstra   +3 more
doaj   +1 more source

Skin cleansing and emolliating for older people: A quasi-experimental pilot study. [PDF]

, 2017
AIMS: The aims of this study were to (i) assess the effect of low-cost hygiene and emollient regimens on the skin barrier function (SBF) of people aged >65 year with xerosis (dry skin) on their lower legs; (ii) to assess the utility of portable measures ...
Ali, Ananthapadmanabhan, Atrux-Tallau, Balaskas, Baranda, Baranoski, Beauregard, Benbow, Burr, Carville, Chrit, Cole, Cowdell, Cowdell, Cowdell, Draelos, Dyble, Ersser, Ersser, Ferguson, Finch, Fluhr, Fluhr, Fore, Gardiner, Gloor, Harding, Holden, Hunter, Iiyama, Kottner, Lawton, Levi, Lodén, Moncrieff, Nash, Overgaard-Olsen, Plessis, Ramsing, Rawlings, Roussel, Voegeli, Warner, Warner, Watkins, Wolf   +45 more
core   +2 more sources

Epidermal Skin Barrier

Asian Journal of Beauty and Cosmetology, 2016
표피의 각질형성세포가 세포분열과 분화를 거쳐 형성하는 각질층은 피부장벽의 핵심적인 조직이며 이러한 각질층의 형성과정에서 발생하는 불균형과 이상현상은 피부장벽의 기능 이상을 초래한다. 각질층의 기능을 조절하는 인자의 보다 상세한 이해를 위해, 본 논문은 피부장벽을 구성하는 각 요소를 자세히 서술해보았다. “Brick & Mortar” 모델에 따르면, 층판소체, 각질세포막, 지질, 칼슘, 사이토카인, 보습인자 등과 같은 피부장벽의 주된 요소가 자세히 묘사되어 있다. 각질층의 구조와 기능을 설명하는 가장 대표적인 모델은 “Brick & Mortar”로 설명되는 양분 모델이다.
Hyun Hee Jang, Sung Nae Lee
openaire   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source