Development and Characterisation of a Topical Methyl Salicylate Patch: Effect of Solvents on Adhesion and Skin Permeation [PDF]
Pharmaceutics, 2022 The advent of skin patch formulation design and technology has enabled the commercialisation of methyl salicylate (MS) as a topical patch. However, the most fundamental aspect of skin permeation is unknown at present.
Soo Chin Yeoh +3 more
doaj +4 more sources
Prediction of drug permeation through microneedled skin by machine learning
Bioengineering & Translational Medicine, 2023 Stratum corneum is the outermost layer of the skin preventing external substances from entering human body. Microneedles (MNs) are sharp protrusions of a few hundred microns in length, which can penetrate the stratum corneum to facilitate drug permeation
Yunong Yuan +6 more
doaj +2 more sources
IAM Chromatographic Models of Skin Permeation. [PDF]
Molecules, 2022 Chromatographic retention factor log kIAM obtained from IAM HPLC chromatography with buffered aqueous mobile phases and calculated molecular descriptors (surface area—Sa; molar volume—VM; polar surface area—PSA; count of freely rotable bonds—FRB; H-bond acceptor count—HA; energy of the highest occupied molecular orbital—EHOMO; energy of the lowest ...
Sobańska AW, Brzezińska E.
europepmc +4 more sources
Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP). [PDF]
, 2014 Phthalates are suspected to be endocrine disruptors. Di(2-ethylhexyl) phthalate (DEHP) is assumed to have low dermal absorption; however, previous in vitro skin permeation studies have shown large permeation differences.
Berthet, Aurélie +5 more
core +3 more sources
Kombucha as a Potential Active Ingredient in Cosmetics—An Ex Vivo Skin Permeation Study [PDF]
MoleculesKombucha is a non-alcoholic beverage, that is increasingly used in the cosmetic industry. The available literature reports the positive effects of kombucha on the skin, in particular its antioxidant action. However, there is a lack of information on skin
Karolina Jakubczyk +5 more
doaj +2 more sources
Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide
ADMET and DMPK, 2014 The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by the original Czech compound (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, known under the international ...
Josef Jampilek, Radka Opatrilova
doaj +3 more sources
Photodynamic Therapy as a Novel Therapeutic Modality Applying Quinizarin-Loaded Nanocapsules and 3D Bioprinting Skin Permeation for Inflammation Treatment [PDF]
PharmaceuticalsSkin inflammation associated with chronic diseases involves a direct role of keratinocytes in its immunopathogenesis, triggering a cascade of immune responses.
Stéphanie R. do Amaral +7 more
doaj +2 more sources
Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation [PDF]
Iranian Journal of Basic Medical Sciences, 2014 Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for ...
Soliman Mohammadi-Samani +3 more
doaj +2 more sources
Keratin-Functionalized Transfersomes for Improving the Skin Permeation and Deposition of Podophyllotoxin. [PDF]
ACS OmegaNiu J +7 more
europepmc +3 more sources
Human Skin Permeation Enhancement Using PLGA Nanoparticles Is Mediated by Local pH Changes
Pharmaceutics, 2021 The steady improvement and optimization of transdermal permeation is a constant and challenging pharmaceutical task. In this study the influence of poly(lactide-co-glycolide) (PLGA) nanoparticles on the dermal permeation of the anti-inflammatory drug ...
Javiana Luengo +4 more
doaj +1 more source