Results 41 to 50 of about 31,339 (306)

Effect of continuous phase drug concentration, evaporation and partitioning on transdermal drug permeation kinetics with lipophilic vehicles [PDF]

open access: yes, 2008
In this work the dependence of transdermal drug permeation kinetics on continuous phase drug concentration, partitioning between formulation phases, partitioning between stratum corneum and continuous oil phase and evaporation of volatile formulation ...
Reiser, Miriam Regina Luise
core   +1 more source

Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

open access: yesADMET and DMPK, 2014
The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by the original Czech compound (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, known under the international ...
Josef Jampilek, Radka Opatrilova
doaj   +1 more source

Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen

open access: yesDrug Delivery, 2017
The film forming gel, adhered to skin surfaces upon application and formed a film, has an advantage onto skin to provide protection and continuous drug release to the application site.
Dong-Won Oh   +11 more
doaj   +1 more source

Surfactant and temperature effects on paraben transport through silicone membranes

open access: yes, 2013
This study investigates the effects of two surfactants (one anionic and one non-ionic) and controlled modifications in temperature (298–323 K) on the permeation of two structurally similar compounds through a silicone membrane using a Franz diffusion ...
Bibi, Aisha   +3 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang   +10 more
wiley   +1 more source

Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion

open access: yesJournal of Nanobiotechnology, 2008
Background Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects.
Ali Javed   +4 more
doaj   +1 more source

Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling

open access: yes, 2019
Vitamin C (ascorbic acid) is a naturally occurring, powerful anti-oxidant with the potential to deliver numerous benefits to the skin when applied topically.
Scurr, David J.   +7 more
core   +1 more source

Engineering Pendant Group Chemistry to Control Hydrophilicity and Oxidative Degradation of Thioketal‐Based Biomaterials

open access: yesAdvanced Functional Materials, EarlyView.
Thioketal (TK) polymers are promising biomaterials due to their selective biodegradation by reactive oxygen species (ROS), but they respond slowly to physiologic doses of ROS. Here, the TK bond's pendant groups are modified to enhance the degradation of TK‐based implants both in vitro and in vivo.
Karina A. Bruce   +6 more
wiley   +1 more source

Dependence of skin drug permeation on microstructure and time dependent alterations following application of more-phasic dermatological formulations studied by the continuous phase drug concentration concept [PDF]

open access: yes, 2006
In this work, the dependence of transdermal delivery of hydrophilic drugs on mass fraction and microstructure of dispersed phase of multi-phase dermatological o/w formulations was studied.
Nalenz, Heiko
core   +1 more source

A Skin‐Like Strain Sensor for Real‐Time Human Motion Detection

open access: yesAdvanced Functional Materials, EarlyView.
A skin‐like strain sensor with exceptional flexibility and breathability enables real‐time human motion detection. It offers continuous ECG monitoring and gesture recognition, ensuring high durability and comfort. This innovative design is ideal for wearable applications, combining reliable performance with seamless integration into dynamic ...
Shiqi Song   +5 more
wiley   +1 more source

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