Results 21 to 30 of about 31,339 (306)

The Phenion (R) Full-Thickness Skin Model for Percutaneous Absorption Testing [PDF]

, 2010
In recent years many efforts have been made to replace dermal toxicity testing of chemicals in the animal by in vitro assays. As a member of a German research consortium, we have previously contributed to the validation of an in vitro test protocol for ...
Korting, Hans Christian, Ackermann, K., Schäfer-Korting, Monika, Borgia, S. Lombardi, Mewes, K. R.   +4 more
core   +1 more source

Mathematical Model to Predict Skin Concentration after Topical Application of Drugs

Pharmaceutics, 2013
Skin permeation experiments have been broadly done since 1970s to 1980s as an evaluation method for transdermal drug delivery systems. In topically applied drug and cosmetic formulations, skin concentration of chemical compounds is more important than ...
Hiroaki Todo, Takeshi Oshizaka, Wesam R. Kadhum, Kenji Sugibayashi   +3 more
doaj   +1 more source

IN-VITRO STUDIES ON CORTICOSTERONE PERMEATION THROUGH HAIRLESS MOUSE SKIN: ( PART I) [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2003
The use of penetration enhancer adjuvants was emerged as a growing trend intransdermal drug delivery. These adjuvants may reduce the capacity for drug binding to skinand promote the permeation of bimolecules through the skin.
Dalia. Shaker, Eman. El-leithy, Abdel Ghanem, Fahima Hashem   +3 more
doaj   +1 more source

Evaluation of Transdermal Transport and Concurrent Cutaneous Hydrolysis of Timolol Prodrug for the Treatment of Infantile Hemangiomas

Pharmaceutics, 2022
Infantile hemangiomas (IH) leave sequelae after involution. Topical application of timolol maleate (TM) is the mainstream treatment for superficial lesions but is limited by its low penetrable properties.
Shih-Jen Chang, Huiyuan Wang, Jialin Chen, Qianyi Chen, Lei Chang, Yongzhuo Huang, Yajing Qiu, Xiaoxi Lin   +7 more
doaj   +1 more source

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Pharmaceutics, 2020
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant.
Christofori M. R. R. Nastiti, Thellie Ponto, Yousuf Mohammed, Michael S. Roberts, Heather A. E. Benson   +4 more
doaj   +1 more source

Permeation of skin with (C₆₀) fullerene dispersions [PDF]

Engineering in Life Sciences, 2017
Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations.
Sá, M., Azóia, Nuno G., Melle-Franco, Manuel, Ribeiro, Artur, Cavaco-Paulo, Artur   +4 more
openaire   +3 more sources

Enhanced chlorhexidine skin penetration with eucalyptus oil [PDF]

, 2010
Background Chlorhexidine digluconate (CHG) is a widely used skin antiseptic, however it poorly penetrates the skin, limiting its efficacy against microorganisms residing beneath the surface layers of skin. The aim of the current study was to improve the
Conway, Barbara R, Anthony C Hilton, Elliott Tom SJ, Lambert Peter A, Hilton, Anthony C, Karpanen Tarja J, Peter A Lambert, Tarja J Karpanen, Hilton Anthony C, Tony Worthington, Worthington, Tony, Karpanen, Tarja J., Elliott, T.S.J., Lambert, P.A., Karpanen, Tarja J, Worthington, T., Tom SJ Elliott, Hilton, A.C., Elliott, Tom S J, Conway Barbara R, Hilton, Anthony C., Worthington Tony, Conway, Barbara R., Karpanen, T.J., Lambert, Peter A, Lambert, Peter A., Barbara R Conway   +26 more
core   +1 more source

Temperature influencing permeation pattern of alfuzosin: An investigation using DoE

Medicina, 2015
Background and objective: There has been relatively little investigation of the effect of temperature on skin permeation compared to other methods of penetration enhancement.
Satyanarayan Pattnaik, Kalpana Swain, Jupally Venkateshwar Rao, Talla Varun, Subrata Mallick   +4 more
doaj   +1 more source

Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery

Membranes, 2021
Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved.
Rui Pereira, Sandra G. Silva, Marina Pinheiro, Salette Reis, M. Luísa do Vale   +4 more
doaj   +1 more source

Combined Use of N-Palmitoyl-Glycine-Histidine Gel and Several Penetration Enhancers on the Skin Permeation and Concentration of Metronidazole

Pharmaceutics, 2018
N-Palmitoyl-Glycine-Histidine (Pal-GH) is a novel low molecular weight gelator. In our previous report, ivermectin, a lipophilic drug, was effectively delivered to skin tissue after topical application with Pal-GH as a spray gel formulation, and a much ...
Sabrina Dahlizar, Mika Futaki, Akie Okada, Chihiro Yatomi, Hiroaki Todo, Kenji Sugibayashi   +5 more
doaj   +1 more source