Results 11 to 20 of about 62,571 (334)
Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds [PDF]
Journal of Pharmaceutical Analysis, 2017 This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created.
Laura J. Waters +4 more
doaj +4 more sources
Prediction of drug permeation through microneedled skin by machine learning
Bioengineering & Translational Medicine, 2023 Stratum corneum is the outermost layer of the skin preventing external substances from entering human body. Microneedles (MNs) are sharp protrusions of a few hundred microns in length, which can penetrate the stratum corneum to facilitate drug permeation
Yunong Yuan +6 more
doaj +1 more source
Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities
Pharmaceutics, 2020 The transdermal route of drugs has received increased attention in recent years due to numerous advantages over the oral and injectable routes, such as avoidance of the hepatic metabolism, protection of drugs from the gastrointestinal tract, sustained ...
Rabin Neupane +4 more
doaj +1 more source
Estimation of skin permeation by liquid chromatography [PDF]
ADMET and DMPK, 2018 Dermal absorption is a key process in the drug delivery studies of the pharmaceutical and cosmetic industries, as well as in the fields of dermal toxicology, risk assessment, and the exposure of environmental pollutants. This process is typically described by the skin-water permeability coefficient.
Soriano Meseguer, Sara +3 more
openaire +4 more sources
Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches
Designed Monomers and Polymers, 2022 Niosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this
Muhammad Khurram Waqas +9 more
doaj +1 more source
Pharmaceutics, 2023 Acyclovir (ACV) controls cutaneous herpes, genital herpes, herpes keratitis, varicella zoster, and chickenpox. From previously reported ACV formulations, we continued to explore the permeation behavior of the optimized ACV loaded optimized ethosome ...
Afzal Hussain +5 more
doaj +1 more source
Skin Permeation of Acyl Derivatives of Stobadine [PDF]
Drug Delivery, 2006 Stobadine is a model drug with pyridoindole structure with cardioprotective and antioxidant properties. Permeation properties of its acyl derivatives were studied to find a proper prodrug form. The experimental study of transdermal delivery of derivatives was combined with the theoretical approach in which the partition coefficients of substances were ...
P Bohov +6 more
openaire +3 more sources
Pharmaceutics, 2022 Infantile hemangiomas (IH) leave sequelae after involution. Topical application of timolol maleate (TM) is the mainstream treatment for superficial lesions but is limited by its low penetrable properties.
Shih-Jen Chang +7 more
doaj +1 more source
Transdermal Permeation of Drugs in Various Animal Species
Pharmaceutics, 2017 Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and effect of topically-applied drugs by measuring its skin permeation and concentration. However, ethical considerations are the major problem for using human skin
Hiroaki Todo
doaj +1 more source
Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP). [PDF]
, 2014 Phthalates are suspected to be endocrine disruptors. Di(2-ethylhexyl) phthalate (DEHP) is assumed to have low dermal absorption; however, previous in vitro skin permeation studies have shown large permeation differences.
Berthet, Aurélie +5 more
core +1 more source