Results 31 to 40 of about 120,490 (202)

The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input [PDF]

, 2014
Descending controls of spinal nociceptive processing play a critical role in the development of inflammatory hyperalgesia. Acute peripheral nociceptor sensitization drives spinal sensitization and activates spino–supraspinal–spinal loops leading to ...
Andrew, Asante, Bajic, Blake, Boada, Bridget M. Lumb, Campbell, Chillingworth, Clarke, Cook, Cook, Davis, DeFelice, Djouhri, Djouhri, Dogrul, Donaldson, Du, Dunham, Fields, Green, Guan, Harris, Horiguchi, Howorth, Hughes, Hylden, Iadarola, Ikeda, Jeong, Kauppila, Kocher, Koerber, Kwok, Latremoliere, Leem, Leith, Liu, Lucy F. Donaldson, Lynn, Magerl, Mantyh, Mantyh, McMullan, McMullan, McMullan, Meyer, Meyer, Miki, Millan, Millan, Oliva, Ossipov, Ossipov, Paalzow, Palazzo, Pertovaara, Pertovaara, Provitera, Przewłocki, Reed, Ren, Ren, Richard P. Hulse, Robert A. R. Drake, Sandrini, Schouenborg, Sivilotti, Soignier, Stanfa, Størkson, Suzuki, Takano, Terayama, Tsuruoka, Tsuruoka, Tsuruoka, Tyce, Vanegas, Vasquez, Wang, Westlund, Wiesenfeld-Hallin, Woolf, Yeomans, Yoshimura, You, Yu, Zhang, Ziegler   +89 more
core   +2 more sources

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source

Research Progress on Alternative Methods of Skin Sensitization Test

Shiyan dongwu yu bijiao yixue, 2022
Allergic contact dermatitis is a type Ⅳ hypersensitivity reaction caused by repeated skin exposure to a substance and is a common public health problem. Traditional skin sensitization tests are based on animal experiments such as guinea pig maximum test ...
HUANG Jingyi, LI Peining, LIU Xiangmei, LIU Zhonghua, HUANG Yufeng   +4 more
doaj   +1 more source

Preserved cellular immunity in smoldering acute leukemia [PDF]

, 1976
"Smoldering acute leukemia", a variant of acute myelogenous leukemia, has been recognized with frequent incidence in recent years. This is chracterized by benign clinical course, poor physical findings, leukopenia and mild anemia in the ...
Toki, Hironobu
core   +1 more source

Doubling your payoff: winning pain relief engages endogenous pain inhibition [PDF]

, 2015
When in pain, pain relief is much sought after, particularly for individuals with chronic pain. In analogy to augmentation of the hedonic experience (“liking”) of a reward by the motivation to obtain a reward (“wanting”), the seeking of pain relief in ...
Ahmed, Alysha-Karima, Becker, Susanne, Gandhi, Wiebke, Kwan, Saskia, Schweinhardt, Petra   +4 more
core   +1 more source

Differential susceptibility between skin and vaginal mucosa in sensitization phase of allergic contact dermatitis in mice

Immunity, Inflammation and Disease, 2020
Introduction Mechanisms underlying skin sensitization in allergic contact dermatitis have been actively studied using the murine contact hypersensitivity (CHS) model. However, much less is known about sensitization at the vaginal mucosa (VM).
Taku Nishijo, Kanako Nakayama, Masaaki Miyazawa, Yasutaka Kuroda, Hitoshi Sakaguchi   +4 more
doaj   +1 more source

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]

, 2019
Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara, Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, E.M. Willemsen, Linette, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, H.M. van Bilsen, Jolanda, Hayen, Simone, L. Bavaro, Simona, L. Roggen, Erwin, Lozano-Ojalvo, Daniel, M. Antunes, Célia, Wróblewska, Mónica   +14 more
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Sensitive skin: an overview [PDF]

International Journal of Cosmetic Science, 2012
SynopsisSensitive skin is a condition of subjective cutaneous hyper‐reactivity to environmental factors. Subjects experiencing this condition report exaggerated reactions when their skin is in contact with cosmetics, soaps and sun screens, and they often report worsening after exposure to dry and cold climate. Although no sign of irritation is commonly
E, Berardesca, M, Farage, H, Maibach
openaire   +2 more sources

A comprehensive review of the Direct Peptide Reactivity Assay in skin sensitization testing: Applicability, limitations, and considerations [PDF]

Arhiv za farmaciju
Skin sensitization is a crucial endpoint in the safety assessment of chemicals, with the Direct Peptide Reactivity Assay (DPRA) emerging as a valuable in chemico method for evaluating a substance's sensitization potential.
Omeragić Elma, Imamović Belma, Dedić Mirza, Mujezin Indira, Bečić Ervina   +4 more
doaj   +1 more source

The clinical meaning of histamine skin reactivity [PDF]

, 2015
The definition of the “atopic state”, i.e. subjects presenting at least one skin wheal with a minimum diameter of 3 mm induced by an allergen skin-prick test (ASPT), is based on the assumption that wheal size depends entirely on the amount of histamine
BARRETO, Mario, RONCHETTI, ROBERTO
core   +1 more source