Results 81 to 90 of about 1,383,486 (355)

Skin Testing with Inhaled Allergens: A Family Physician's Experience

open access: yesSouth African Family Practice, 1990
No abstract available.
R.J.E. Erasmus
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Effect of stressed skin action on the behaviour of cold-formed steel portal frames [PDF]

open access: yes, 2015
This paper describes a series of six full-scale laboratory tests conducted on cold-formed steel portal frame buildings in order to investigate the effects of joint flexibility and stressed skin diaphragm action.
Lawson, R. M.   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

American cutaneous leishmaniasis: use of a skin test as a predictor of relapse after treatment

open access: yesBulletin of the World Health Organization, 2000
While relapses following clinical cure of American cutaneous leishmaniasis are frequent, no test has been described until now to predict such relapses.
Valéria M.A. Passos   +5 more
doaj  

A Narrative Review on Evaluation of Causal Drug in Cutaneous Drug Eruptions: Challenges, Current State, and the Path Ahead

open access: yesInternational Journal of Advanced Medical and Health Research
The diagnosis of cutaneous drug reactions is challenging, particularly when it involves the identification of the culprit drug. This exercise is, however, essential, as re-prescription of the offending drug is harmful to the patient while holding back an
Sivaranjini Ramassamy
doaj   +1 more source

Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function [PDF]

open access: yes, 2011
Objective: To compare the inter-day reproducibility of post-occlusive reactive hyperaemia (PORH) and sympathetic vasomotor reflexes assessed by single-point laser Doppler flowmetry (SP-LDF), integrating-probe LDF (IP-LDF) and laser speckle contrast ...
Briers, J. David   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Staphylococcal enterotoxin sensitization in a community-based population : a potential role in adult-onset asthma [PDF]

open access: yes, 2014
Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations.
Bachert, Claus   +11 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

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