Results 1 to 10 of about 140 (79)
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019.
Rodrigo De Vecchi +8 more
doaj +7 more sources
The importance of the neuro‐immuno‐cutaneous system on human skin equivalent design
Cell Proliferation, Volume 52, Issue 6, November 2019., 2019 The skin is a highly complex, sensory organ composed of three main layers: epidermis, dermis and hypodermis, and numerous cell types which interact to make up the neuro‐immuno‐cutaneous (NIC) system. The skin is a sensory organ, responding to various stimuli through orchestrated cellular and molecular signals.
Sarah E. Vidal Yucha +2 more
wiley +1 more source
Tempol Ameliorates Psoriatic Skin Inflammation: Evidence of TLR4/NF‐κB/Nrf2 Axis Modulation
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, immune dysregulation, oxidative stress, and impaired epidermal barrier function. In the present study, we investigated the protective effects of Tempol, a membrane‐permeable nitroxide with antioxidant and anti‐inflammatory properties, using several ...
Sarah Adriana Scuderi +6 more
wiley +1 more source
Contact Dermatitis, Volume 93, Issue 3, Page 187-203, September 2025.ABSTRACT Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should ...
Meital Portugal‐Cohen +9 more
wiley +1 more source
Journal of Cosmetic Dermatology, Volume 24, Issue 7, July 2025.ABSTRACT Extracellular vesicles (EVs) derived from plant sources, particularly apple‐derived vesicles (ADVs), have gained interest for their biocompatibility and bioactive properties in cosmetic, dermatological, and regenerative medicine applications.
Lucia Sileo +5 more
wiley +1 more source
Guidance on the use of read‐across for chemical safety assessment in food and feed
EFSA Journal, Volume 23, Issue 7, July 2025.Abstract Read‐across is a method used in chemical risk assessment to predict the toxicological properties of a target substance by using data from structurally and mechanistically similar substances, known as source substances. EFSA's Scientific Committee has developed an approach for using read‐across in food and feed risk assessment.
EFSA Scientific Committee +26 more
wiley +1 more source
Vascularized 3D Human Skin Models in the Forefront of Dermatological Research
Advanced Healthcare Materials, Volume 13, Issue 9, April 5, 2024.Vascularized human skin models are an emerging alternate platform for drug testing. The need for incorporation of blood vessels within in vitro models emerges from the fact that skin diseases and the ensuing therapy influence vessel morphology, functionality, and growth.
Rahul Rimal +7 more
wiley +1 more source
Journal of Applied Toxicology, Volume 44, Issue 3, Page 333-343, March 2024.Abstract The HUMIMIC skin‐liver Chip2 microphysiological systems model using the epidermal model, EpiDerm™, was reported previously to mimic application route‐dependent metabolism of the hair dye, 4‐amino‐2‐hydroxytoluene (AHT). Therefore, we evaluated the use of alternative skin models—SkinEthic™, EpiDermFT™ and PhenionFT™—for the same purpose.
Katrin Brandmair +8 more
wiley +1 more source
BioMed Research International, Volume 2024, Issue 1, 2024.The development of technologies for the generation and transplantation of living skin equivalents (LSEs) is a significant area of translational medicine. Such functional equivalents can be used to model and study the morphogenesis of the skin and its derivatives, to test drugs, and to improve the healing of chronic wounds, burns, and other skin ...
Andrei Riabinin +6 more
wiley +1 more source
The "Big Three" in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation-are we there yet? [PDF]
Front Toxicol, 2023 Kanďárová H, Pôbiš P.
europepmc +1 more source