Results 1 to 10 of about 128,731 (159)

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]

BMC Cancer, 2019
Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte, Annette Künkele   +15 more
doaj   +6 more sources

A Comparison of Osteoblast and Osteoclast In Vitro Co-Culture Models and Their Translation for Preclinical Drug Testing Applications [PDF]

International Journal of Molecular Sciences, 2020
As the population of western societies on average ages, the number of people affected by bone remodeling-associated diseases such as osteoporosis continues to increase. The development of new therapeutics is hampered by the high failure rates of drug candidates during clinical testing, which is in part due to the poor predictive character of animal ...
Elena della Bella, Piergiorgio Gentile, Alexander Sieberath   +2 more
exaly   +6 more sources

Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies [PDF]

European Journal of Pharmaceutical Sciences, 2017
The pharmaceutical development of new chemical entities can be hampered by their solubility and/or dissolution limitations. Currently, these properties are characterised mostly during in vivo pre-clinical studies. The development of appropriate in vitro methods to study the solubility and dissolution properties in preclinical species would lead to a ...
Robert Taylor, Nikoletta Fotaki, Karl J Box   +2 more
exaly   +4 more sources

In Vitro and In Vivo Preclinical Testing of Pericyte‐Engineered Grafts for the Correction of Congenital Heart Defects [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We have previously reported the possibility of using pericytes from leftovers of palliative surgery of congenital heart disease to engineer clinically certified prosthetic grafts.
Valeria Vincenza Alvino, Michael Kilcooley, Anita C. Thomas, Michele Carrabba, Marco Fagnano, William Cathery, Elisa Avolio, Dominga Iacobazzi, Mohamed Ghorbel, Massimo Caputo, Paolo Madeddu   +10 more
doaj   +5 more sources

Human atrium-sized in vitro modelling of atrial fibrillation: a new experimental scale for preclinical therapeutic testing [PDF]

Europace
Abstract Background Atrial size strongly influences atrial fibrillation (AF) development, maintenance, and therapeutic outcome, including pharmacological cardioversion. Despite this, preclinical research relies heavily on models considerably smaller than the human atrium, such as cell-based and
A Nobacht, T De Coster, S Deng, J Zhang, S O Dekker, B L Den Ouden, M R Rivaud, A P Wijnmalen, S A Trines, V Portero, B J Boukens, A A F De Vries, D A Pijnappels   +12 more
europepmc   +2 more sources

Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro [PDF]

Viruses, 2017
Osteosarcoma is the most frequent malignant disease of the bone. On the basis of early clinical experience in the 1960s with H-1 protoparvovirus (H-1PV) in osteosarcoma patients, this effective oncolytic virus was selected for systematic preclinical ...
Carsten Geiss, Zoltán Kis, Barbara Leuchs, Monika Frank-Stöhr, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart, Jeannine Lacroix   +7 more
doaj   +6 more sources

Modern methods of preclinical anticancer drug screening using test systems based on cell cultures

Учёные записки Казанского университета: Серия Естественные науки, 2021
Preclinical screening of medicinal drugs for novel anti-cancer treatments faces a problem of a rational approach to primary screening of substances with antitumor activity. Low correlation between in vitro and in vivo studies with clinical trials remains
K.V. Kitaeva, A.A. Rizvanov, V.V. Solovyeva   +2 more
doaj   +1 more source

Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma

Cells, 2023
Sinonasal teratocarcinosarcoma (TCS) is a rare tumor that displays a variable histology with admixtures of epithelial, mesenchymal, neuroendocrine and germ cell elements.
Sara Lucila Lorenzo-Guerra, Helena Codina-Martínez, Laura Suárez-Fernández, Virginia N. Cabal, Rocío García-Marín, Cristina Riobello, Blanca Vivanco, Verónica Blanco-Lorenzo, Paula Sánchez-Fernández, Fernando López, Jóse Luis Llorente, Mario A. Hermsen   +11 more
doaj   +1 more source

An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

Pharmaceutics, 2022
The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in ...
Hannes Gierke, Kerstin Schaefer, Lukas Gerlich, Ann-Cathrin Willmann, Verena Bialetzki, Georg Boeck, Teresa Pfrommer, Thomas Nolte, Werner Weitschies   +8 more
doaj   +1 more source

Ventilation‐induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti‐inflammatory therapeutics

Bioengineering & Translational Medicine, 2022
Mortality rates among patients suffering from acute respiratory failure remain perplexingly high despite the maintenance of blood oxygen homeostasis during ventilatory support.
Eliram Nof, Arbel Artzy‐Schnirman, Saurabh Bhardwaj, Hadas Sabatan, Dan Waisman, Ori Hochwald, Maayan Gruber, Liron Borenstein‐Levin, Josué Sznitman   +8 more
doaj   +1 more source