Results 1 to 10 of about 130,065,242 (295)
The in vitro human fracture hematoma model – a tool for preclinical drug testing
ALTEX: Alternatives to Animal Experimentation, 2020 The aim of the study was to establish an in vitro fracture hematoma (FH) model that mimics the in vivo situation of the human fracture gap in order to assess drug efficacy and effectiveness for the treatment of fracture healing disorders.
Moritz Pfeiffenberger +5 more
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Development of In Vitro Corneal Models: Opportunity for Pharmacological Testing [PDF]
Methods and Protocols, 2020 The human eye is a specialized organ with a complex anatomy and physiology, because it is characterized by different cell types with specific physiological functions.
Valentina Citi +4 more
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Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery
Biosensors and Bioelectronics: X, 2022 The core of the drug research and screening processes is predicting the effect of drugs prior to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the cost of drug discovery is continuously rising.
Tanvir Ahmed
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Life, 2022 Duchenne muscular dystrophy (DMD) is the most frequent genetic myopathy in childhood and leads to progressive muscle atrophy, weakness, and premature death. So far, there is no curative treatment available.
Tina Donandt +6 more
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Developing preclinical models of neuroblastoma: driving therapeutic testing
BMC Biomedical Engineering, 2019 Despite advances in cancer therapeutics, particularly in the area of immuno-oncology, successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common cancer in infants under 1 year of age, and accounts for approximately 10% of all ...
Kimberly J. Ornell, Jeannine M. Coburn
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Heterotypic Multicellular Spheroids as Experimental and Preclinical Models of Sprouting Angiogenesis
Biology, 2021 Sprouting angiogenesis is the common response of live tissues to physiological and pathological angiogenic stimuli. Its accurate evaluation is of utmost importance for basic research and practical medicine and pharmacology and requires adequate ...
Igor V. Vakhrushev +6 more
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Experimental Cell Line Models for Nephrotoxicity Screening
Регуляторные исследования и экспертиза лекарственных средств, 2021 The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo ...
I. A. Mazerkina +4 more
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The benefits and limitations of animal models for translational research in cartilage repair
Journal of Experimental Orthopaedics, 2016 Much research is currently ongoing into new therapies for cartilage defect repair with new biomaterials frequently appearing which purport to have significant regenerative capacity.
Conor J. Moran +5 more
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Bone defect animal models for testing efficacy of bone substitute biomaterials
Journal of Orthopaedic Translation, 2015 Large bone defects are serious complications that are most commonly caused by extensive trauma, tumour, infection, or congenital musculoskeletal disorders.
Ye Li +5 more
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APL Bioengineering, 2023 Low back pain is the leading cause of disability, producing a substantial socio-economic burden on healthcare systems worldwide. Intervertebral disc (IVD) degeneration is a primary cause of lower back pain, and while regenerative therapies aimed at full ...
Daniela Lazaro-Pacheco +4 more
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