, 2022 S.1570-1575Higher throughput methods, high content analysis and automated screening methods are of highest demand in drug development today. In toxicology, these strategies are becoming increasingly important, as well.
Ritter, D., Knebel, J.
core +1 more source
Heterotypic Multicellular Spheroids as Experimental and Preclinical Models of Sprouting Angiogenesis
Biology, 2021 Sprouting angiogenesis is the common response of live tissues to physiological and pathological angiogenic stimuli. Its accurate evaluation is of utmost importance for basic research and practical medicine and pharmacology and requires adequate ...
Igor V. Vakhrushev +6 more
doaj +1 more source
Sarcopenia Detection System Using RGB-D Camera and Ultrasound Probe: System Development and Preclinical In-Vitro Test [PDF]
Sensors, 2020 Sarcopenia is defined as muscle mass and strength loss with aging. As places, such as South Korea, Japan, and Europe have entered an aged society, sarcopenia is attracting global attention with elderly health. However, only few developed devices can quantify sarcopenia diagnosis modalities. Thus, the authors developed a sarcopenia detection system with
Yeoun-Jae Kim +2 more
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Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration. [PDF]
, 2013 Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa +18 more
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Bone defect animal models for testing efficacy of bone substitute biomaterials
Journal of Orthopaedic Translation, 2015 Large bone defects are serious complications that are most commonly caused by extensive trauma, tumour, infection, or congenital musculoskeletal disorders.
Ye Li +5 more
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Experimental Cell Line Models for Nephrotoxicity Screening
Регуляторные исследования и экспертиза лекарственных средств, 2021 The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo ...
I. A. Mazerkina +4 more
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In Vitro Primary Cell Culture as a Physiologically Relevant Method for Preclinical Testing of Human Oncolytic Adenovirus [PDF]
Human Gene Therapy, 2012 Ad[I/PPT-E1A] is an oncolytic adenovirus that specifically kills prostate cells via restricted replication by a prostate-specific regulatory element. Off-target replication of oncolytic adenoviruses would have serious clinical consequences. As a proposed ex vivo test, we describe the assessment of the specificity of Ad[I/PPT-E1A] viral cytotoxicity and
Adamson, R. E. +9 more
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Establishment of contaminant-free perennial plants in vitro
, 1999 Perennial plant tissue cultures are established by disinfecting field or greenhouse-grown plant parts and transferring them to sterile medium in vitro. Typically, shoots harvested from field or greenhouse-grown plants are placed in water, either to force
McMeans O.M. +5 more
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In Vitro Antibiotic Susceptibilities of Ocular Isolates in North and South America
, 1998 PURPOSETo assess the in vitro susceptibility of ocular bacterial isolates from North and South America to antiinfectives that are commonly used in the treatment of external ocular infection.
In Vitro Antibiotic Testing Grp +2 more
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The benefits and limitations of animal models for translational research in cartilage repair
Journal of Experimental Orthopaedics, 2016 Much research is currently ongoing into new therapies for cartilage defect repair with new biomaterials frequently appearing which purport to have significant regenerative capacity.
Conor J. Moran +5 more
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