Small-scale skeletal muscle constructs for in-vitro musculoskeletal junction preclinical testbed [Abstract] [PDF]
, 2013 Small-scale skeletal muscle constructs for in-vitro musculoskeletal junction preclinical testbed ...
Mark Lewis (1255254) +3 more
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Preclinical Testing Techniques: Paving the Way for New Oncology Screening Approaches
, 2023 Prior to clinical trials, preclinical testing of oncology drug candidates is performed by evaluating drug candidates with in vitro and in vivo platforms. For in vivo testing, animal models are used to evaluate the toxicity and efficacy of drug candidates.
Evan Stefanek +2 more
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A Comparison of Osteoblast and Osteoclast In Vitro Co-Culture Models and Their Translation for Preclinical Drug Testing Applications [PDF]
International Journal of Molecular Sciences, 2020 As the population of western societies on average ages, the number of people affected by bone remodeling-associated diseases such as osteoporosis continues to increase. The development of new therapeutics is hampered by the high failure rates of drug candidates during clinical testing, which is in part due to the poor predictive character of animal ...
Sieberath, Alexander +5 more
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Preclinical Safety Assessment: In vitro – in vivo Testing [PDF]
Pharmacology & Toxicology, 2000 Abstract: In vitro – and in vivo preclinical safety tests on drug candidates needed before first dose in man and before marketing authorisation are as follows: The acute and repeated dose toxicity studies, the reproductive toxicity studies, the ...
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Characterization of phototoxicity reactions in human and animal skin models [PDF]
, 2013 Phototoxicity is a relatively common phenomenon and is an adverse effect of some systemic drugs. A large number of pharmaceutical drug substances are known to carry the potential to elicit a phototoxic response (Moore 2002, Ferguson 2002). Reported cases
Boudon, Stéphanie
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Nucleic Acid Therapeutics, 2022 Antisense oligonucleotides (ASOs) can modulate pre-mRNA splicing. This offers therapeutic opportunities for numerous genetic diseases, often in a mutation-specific and sometimes even individual-specific manner. Developing therapeutic ASOs for as few as even a single patient has been shown feasible with the development of Milasen for an individual with ...
Aartsma-Rus, A. +8 more
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Ex vivo Bone Models and Their Potential in Preclinical Evaluation [PDF]
, 2021 PURPOSE OF REVIEW: Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies.
S. Hofmann +5 more
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Initial Testing of Topotecan by the Pediatric Preclinical Testing Program [PDF]
, 2010 Background. Topotecan is a small molecule DNA topoisomerase poison, that has been successful in clinical trials against pediatric solid tumors and leukemias. Topotecan was evaluated against the Pediatric Preclinical Testing Program (PPTP) tumor panels as
Houghton, PJ +11 more
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Sarcopenia Detection System Using RGB-D Camera and Ultrasound Probe: System Development and Preclinical In-Vitro Test [PDF]
Sensors, 2020 Sarcopenia is defined as muscle mass and strength loss with aging. As places, such as South Korea, Japan, and Europe have entered an aged society, sarcopenia is attracting global attention with elderly health. However, only few developed devices can quantify sarcopenia diagnosis modalities. Thus, the authors developed a sarcopenia detection system with
Yeoun-Jae Kim +2 more
openaire +3 more sources
Improving preclinical models of HIV microbicide efficacy [PDF]
, 2015 Despite potent in vitro efficacy, most topical microbicides fail to effectively prevent HIV transmission. One reason for clinical failure may be that current microbicide testing does not reflect the environment encountered during sexual virus ...
Roan, Nadia R, Münch, Jan
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