Results 11 to 20 of about 114,465,275 (302)

Preclinical in vitro evaluation of implantable materials: conventional approaches, new models and future directions

Frontiers in Bioengineering and Biotechnology, 2023
Nowadays, implants and prostheses are widely used to repair damaged tissues or to treat different diseases, but their use is associated with the risk of infection, inflammation and finally rejection.
Emilie Frisch, Lisa Clavier, Lisa Clavier, Abdessamad Belhamdi, Nihal Engin Vrana, Philippe Lavalle, Philippe Lavalle, Philippe Lavalle, Benoît Frisch, Béatrice Heurtault, Varvara Gribova, Varvara Gribova   +11 more
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Development of In Vitro Corneal Models: Opportunity for Pharmacological Testing [PDF]

Methods and Protocols, 2020
The human eye is a specialized organ with a complex anatomy and physiology, because it is characterized by different cell types with specific physiological functions.
Valentina Citi, Eugenia Piragine, Simone Brogi, Sara Ottino, Vincenzo Calderone   +4 more
doaj   +2 more sources

A Novel Preclinical In Vitro 3D Model of Oral Carcinogenesis for Biomarker Discovery and Drug Testing

International Journal of Molecular Sciences, 2023
This study aimed to develop an in vitro three-dimensional (3D) cell culture model of oral carcinogenesis for the rapid, scalable testing of chemotherapeutic agents. Spheroids of normal (HOK) and dysplastic (DOK) human oral keratinocytes were cultured and treated with 4-nitroquinoline-1-oxide (4NQO).
Ravi Teja Chitturi Suryaprakash, Kate Shearston, Camile S. Farah, Simon A. Fox, Muhammad Munir Iqbal, Ulrich Kadolsky, Xiao Zhong, Alka Saxena, Omar Kujan   +8 more
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OP0244 A PRECLINICAL TESTING TOOL: THE IN VITRO 3D FRACTURE GAP MODEL [PDF]

Annals of the Rheumatic Diseases, 2020
Background: Approximately 10% of fractures lead to significant fracture healing disorders, with a tendency to further increase due to the aging population. Of note, especially immunosuppressed patients with ongoing inflammation show difficulties in the correct course of fracture healing leading to fracture healing disorders.
M. Pfeiffenberger, A. Damerau, P. Hoff, A. Lang, F. Buttgereit, T. Gaber   +5 more
openaire   +1 more source

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

Frontiers in Bioengineering and Biotechnology, 2020
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern.
Kristina V. Kitaeva, Catrin S. Rutland, Albert A. Rizvanov, Albert A. Rizvanov, Valeriya V. Solovyeva   +4 more
doaj   +1 more source

Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development

Bioengineering, 2022
Developing novel drug formulations and progressing them to the clinical environment relies on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity.
Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Hanwen Xing, Daniela Traini, Paul M. Young, Hui Xin Ong   +6 more
doaj   +1 more source

An in vitro model for preclinical testing of endocrine therapy combinations for prostate cancer [PDF]

The Prostate, 2010
AbstractBACKGROUNDEven though patients with prostate cancer commonly respond to endocrine treatment, in most cases the disease progresses to castration resistant prostate cancer (CRPC). Our objective was to generate a novel cell line model representing the endocrine treatment naive prostate cancer for testing treatments that target the androgen ...
Pfeiffer, M.J., Mulders, P.F.A., Schalken, J.A.   +2 more
openaire   +3 more sources

An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules. [PDF]

PLoS ONE, 2018
Robust preclinical testing is essential to predict clinical safety and efficacy and provide data to determine safe dose for first-in-man studies. There are a growing number of examples where the preclinical development of drugs failed to adequately ...
Jane Harper, Katherine J Adams, Giovanna Bossi, Debbie E Wright, Andrea R Stacey, Nicole Bedke, Ruth Martinez-Hague, Dan Blat, Laure Humbert, Hazel Buchanan, Gabrielle S Le Provost, Zoe Donnellan, Ricardo J Carreira, Samantha J Paston, Luise U Weigand, Martina Canestraro, Joseph P Sanderson, Sophie Botta Gordon-Smith, Kate L Lowe, Karolina A Rygiel, Alex S Powlesland, Annelise Vuidepot, Namir J Hassan, Brian J Cameron, Bent K Jakobsen, Joseph Dukes   +25 more
doaj   +1 more source

The in vitro human fracture hematoma model - a tool for preclinical drug testing

ALTEX, 2020
The aim of the study was to establish an in vitro fracture hematoma (FH) model, which mimics the in vivo situation of the human fracture gap in order to assess drug efficacy and effectiveness for the treatment of fracture healing disorders. Therefore, human peripheral blood and mesenchymal stromal cells (MSCs) were coagulated to produce in vitro FH ...
Moritz, Pfeiffenberger, Paula, Hoff, Christa, Thöne-Reineke, Frank, Buttgereit, Annemarie, Lang, Timo, Gaber   +5 more
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National Cancer Institute pediatric preclinical testing program: Model description for in vitro cytotoxicity testing [PDF]

Pediatric Blood & Cancer, 2010
AbstractBackgroundThe National Cancer Institute (NCI) has established the Pediatric Preclinical Testing Program (PPTP) for testing drugs against in vitro and in vivo childhood cancer models to aid in the prioritization of drugs considered for early phase pediatric clinical trials.ProceduresIn vitro cytotoxicity testing employs a semi‐automated ...
Min H, Kang, Malcolm A, Smith, Christopher L, Morton, Nino, Keshelava, Peter J, Houghton, C Patrick, Reynolds   +5 more
openaire   +2 more sources