Results 11 to 20 of about 130,065,242 (295)
CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]
BMC Cancer, 2019 Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Lena Andersch +15 more
doaj +6 more sources
Frontiers in Bioengineering and Biotechnology, 2023 Nowadays, implants and prostheses are widely used to repair damaged tissues or to treat different diseases, but their use is associated with the risk of infection, inflammation and finally rejection.
Emilie Frisch +11 more
doaj +2 more sources
Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development [PDF]
Bioengineering, 2022 Developing novel drug formulations and progressing them to the clinical environment relies on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity.
Hanieh Gholizadeh +6 more
doaj +2 more sources
International Journal of Molecular Sciences, 2023 This study aimed to develop an in vitro three-dimensional (3D) cell culture model of oral carcinogenesis for the rapid, scalable testing of chemotherapeutic agents. Spheroids of normal (HOK) and dysplastic (DOK) human oral keratinocytes were cultured and treated with 4-nitroquinoline-1-oxide (4NQO).
Ravi Teja Chitturi Suryaprakash +8 more
openaire +3 more sources
Modern methods of preclinical anticancer drug screening using test systems based on cell cultures
Учёные записки Казанского университета: Серия Естественные науки, 2021 Preclinical screening of medicinal drugs for novel anti-cancer treatments faces a problem of a rational approach to primary screening of substances with antitumor activity. Low correlation between in vitro and in vivo studies with clinical trials remains
K.V. Kitaeva +2 more
doaj +2 more sources
Preclinical models in radiation oncology [PDF]
Radiation Oncology, 2012 As the incidence of cancer continues to rise, the use of radiotherapy has emerged as a leading treatment modality. Preclinical models in radiation oncology are essential tools for cancer research and therapeutics.
Kahn Jenna +2 more
doaj +2 more sources
Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro [PDF]
Viruses, 2017 Osteosarcoma is the most frequent malignant disease of the bone. On the basis of early clinical experience in the 1960s with H-1 protoparvovirus (H-1PV) in osteosarcoma patients, this effective oncolytic virus was selected for systematic preclinical ...
Carsten Geiss +7 more
doaj +6 more sources
Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research
Pharmaceutics, 2020 Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing.
Bárbara Pinto +3 more
doaj +2 more sources
Cells, 2023 Sinonasal teratocarcinosarcoma (TCS) is a rare tumor that displays a variable histology with admixtures of epithelial, mesenchymal, neuroendocrine and germ cell elements.
Sara Lucila Lorenzo-Guerra +11 more
doaj +1 more source
In Vitro and In Vivo Preclinical Testing of Pericyte‐Engineered Grafts for the Correction of Congenital Heart Defects [PDF]
Journal of the American Heart Association, 2020 Background We have previously reported the possibility of using pericytes from leftovers of palliative surgery of congenital heart disease to engineer clinically certified prosthetic grafts. Methods and Results Here, we assessed the feasibility of using prosthetic conduits ...
Valeria Vincenza Alvino +10 more
openaire +5 more sources