Results 41 to 50 of about 114,465,275 (302)

Long-Term Degradation Assessment of a Polyurethane-Based Surgical Adhesive—Assessment and Critical Consideration of Preclinical In Vitro and In Vivo Testing

Journal of Functional Biomaterials, 2023
Tissue adhesives constitute a great possibility to improve conventional wound closure. In contrast to sutures, they enable nearly immediate hemostasis and can prevent fluid or air leaks. In the present study, a poly(ester)urethane-based adhesive was investigated which already proved to be suitable for different indications, such as reinforcing vascular
Lisanne Bremer, Kerstin Hagemeister, Michaela Moss, Lisa Ernst, René H. Tolba, Stefan Jockenhoevel, Christian Apel   +6 more
openaire   +4 more sources

Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?

, 2020
To date traditional toxicity testing has relied heavily on in-life animal studies that are expensive and restrictive with regards to very important ethical implications. In addition, these studies often yield data that are not relevant to human exposures
Kermanizadeh, A.
core   +1 more source

An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie [PDF]

, 2012
Cost-benefit is rarely combined with nonlinear dynamic models when evaluating control options for infectious diseases. The current strategy for scrapie in Great Britain requires that all genetically susceptible livestock in affected flocks be culled ...
Fiona Houston, Kao, R., Boden, L., Kao, Rowland, Fryer Helen, Hawkins, Neil, Helen Fryer, Handel, I., Boden Lisa, Hawkins, N., Handel Ian, Ian Handel, Fryer, Helen, Houston Fiona, Kao Rowland, Handel, Ian, Hawkins Neil, Rowland Kao, Fryer, H., Boden, Lisa, Houston, Fiona, Lisa Boden, Houston, F., Neil Hawkins   +23 more
core   +1 more source

Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACT This study extends earlier reports regarding the in vitro and in vivo efficacies of the nitroimidazopyran PA-824 against Mycobacterium tuberculosis . PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates ...
Anne J, Lenaerts, Veronica, Gruppo, Karen S, Marietta, Christine M, Johnson, Diane K, Driscoll, Nicholas M, Tompkins, Jerry D, Rose, Robert C, Reynolds, Ian M, Orme   +8 more
openaire   +2 more sources

In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection [PDF]

, 2020
Due to the increasing need of new treatment options against bacterial lung infections, novel antimicrobial peptides (AMPs) are under development. Local bioavailability and less systemic exposure lead to the inhalation route of administration.
Niehof, Monika, Knebel, Jan, Te Welscher, Yvonne, Pharmaceutics, Falciani, Chiara, Gracia, Raquel, Pini, Alessandro, Marradi, Marco, Nostrum, Cornelus F. van, Ritter, Detlef, Loinaz, Iraida, Strandh, Magnus, Hansen, Tanja, Afd Pharmaceutics, van Nostrum, Cornelus F., Welscher, Yvonne te   +15 more
core   +1 more source

The role of biomechanical factors in models of intervertebral disc degeneration across multiple length scales

APL Bioengineering, 2023
Low back pain is the leading cause of disability, producing a substantial socio-economic burden on healthcare systems worldwide. Intervertebral disc (IVD) degeneration is a primary cause of lower back pain, and while regenerative therapies aimed at full ...
Daniela Lazaro-Pacheco, Mina Mohseni, Samuel Rudd, Justin Cooper-White, Timothy Patrick Holsgrove   +4 more
doaj   +1 more source

Effects of collagen gel configuration on behaviour of vascular smooth muscle cells in vitro: association with vascular morphogenesis.

, 2000
The growth, behavior, and contractile protein expression of rabbit aortic smooth muscle cells (SMC) grown on, between layers, or within a collagen gel was investigated by confocal laser scanning fluorescence microscopy and Western analysis.
Campbell, JH, Hayward, IP, Rolfe, BE, Campbell, Gordon R., Campbell, GR, Campbell, Julie H., Hayward, Ian Philip, Rolfe, Barbara E., Song, J, Song, Jian   +9 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source