Results 41 to 50 of about 130,065,242 (295)

In Vitro Primary Cell Culture as a Physiologically Relevant Method for Preclinical Testing of Human Oncolytic Adenovirus [PDF]

Human Gene Therapy, 2012
Ad[I/PPT-E1A] is an oncolytic adenovirus that specifically kills prostate cells via restricted replication by a prostate-specific regulatory element. Off-target replication of oncolytic adenoviruses would have serious clinical consequences. As a proposed ex vivo test, we describe the assessment of the specificity of Ad[I/PPT-E1A] viral cytotoxicity and
Adamson, R. E., Frazier, A. A., Evans, H., Chambers, K. F., Schenk, E., Essand, M., Birnie, R., Mitry, R. R., Dhawan, A., Maitland, N. J.   +9 more
openaire   +3 more sources

In Vitro Antibiotic Susceptibilities of Ocular Isolates in North and South America

, 1998
PURPOSETo assess the in vitro susceptibility of ocular bacterial isolates from North and South America to antiinfectives that are commonly used in the treatment of external ocular infection.
In Vitro Antibiotic Testing Grp, Jensen, Harold, Felix, Carlos   +2 more
core   +1 more source

Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay

, 2022
S.1570-1575Higher throughput methods, high content analysis and automated screening methods are of highest demand in drug development today. In toxicology, these strategies are becoming increasingly important, as well.
Ritter, D., Knebel, J.
core   +1 more source

Formulation Development, Preclinical Testing, and Primary Packaging Optimization for Cannabinoids and Other Therapeutics [PDF]

, 2019
Through the process of drug development, a molecule goes through discovery screening; lead selection and optimization, ADME testing, toxicity profiling, dosage form determination, preclinical testing in an in vitro and in vivo setup, folloby clinical ...
Taskar, Pranjal
core   +1 more source

Long-Term Degradation Assessment of a Polyurethane-Based Surgical Adhesive—Assessment and Critical Consideration of Preclinical In Vitro and In Vivo Testing

Journal of Functional Biomaterials, 2023
Tissue adhesives constitute a great possibility to improve conventional wound closure. In contrast to sutures, they enable nearly immediate hemostasis and can prevent fluid or air leaks. In the present study, a poly(ester)urethane-based adhesive was investigated which already proved to be suitable for different indications, such as reinforcing vascular
Lisanne Bremer, Kerstin Hagemeister, Michaela Moss, Lisa Ernst, René H. Tolba, Stefan Jockenhoevel, Christian Apel   +6 more
openaire   +4 more sources

Establishment of contaminant-free perennial plants in vitro

, 1999
Perennial plant tissue cultures are established by disinfecting field or greenhouse-grown plant parts and transferring them to sterile medium in vitro. Typically, shoots harvested from field or greenhouse-grown plants are placed in water, either to force
McMeans O.M., Özgür, M., Motoike S., Norton M.A., Skirvin R.M., Al-Juboory K.   +5 more
core   +1 more source

Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACT This study extends earlier reports regarding the in vitro and in vivo efficacies of the nitroimidazopyran PA-824 against Mycobacterium tuberculosis . PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates ...
Anne J, Lenaerts, Veronica, Gruppo, Karen S, Marietta, Christine M, Johnson, Diane K, Driscoll, Nicholas M, Tompkins, Jerry D, Rose, Robert C, Reynolds, Ian M, Orme   +8 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source