Results 61 to 70 of about 114,465,275 (302)

Comparative Analysis of Antidiabetic Activities of Caesalpinia bonducella: Mechanisms, and Therapeutic Applications [PDF]

Research Journal of Pharmacognosy
Caesalpinia bonducella is traditionally used for glycemic control. Evidence from in vitro and animal studies has expanded over the last decade but remains fragmented. This review aimed to evaluate the antidiabetic effects of C.
Ami Febriza*, Fityatun Usman, Andi Ulfah Magefirah Rasyid, Zulkifli Halid, Khairunnisa Akib   +4 more
doaj   +1 more source

Celector^®: An Innovative Technology for Quality Control of Living Cells

Applied Sciences, 2022
Among the in vitro and ex vivo models used to study human cancer biology, cancer cell lines are widely utilized. The standardization of a correct tumor model including the stage of in vitro testing would allow for the development of new high-efficiency ...
Silvia Zia, Barbara Roda, Alessia Maggio, Pasquale Marrazzo, Valeria Pizzuti, Francesco Alviano, Laura Bonsi, Valentina Marassi, Andrea Zattoni, Pierluigi Reschiglian   +9 more
doaj   +1 more source

Preclinical developmental toxicity testing and advanced in-vitro stem cell based systems.

, 2021
Therapeutic development and drug discovery processes are heavily challenged by delays in the preclinical experimental stages before being offered for Phase 1 clinical trials. Accelerating the preclinical phase via novel in-vitro systems is need of the hour to help provide effective therapeutics to cure diseases like cancer.
openaire   +2 more sources

In vitro, Tissue-Based Models as a Replacement for Animal Models in Testing of Drugs at the Preclinical Stages [PDF]

, 2012
© 2012 Yand and Xiong., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Zhanqiu Yang, Hai-Rong Xiong
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Preclinical Testing Techniques: Paving the Way for New Oncology Screening Approaches

, 2023
Prior to clinical trials, preclinical testing of oncology drug candidates is performed by evaluating drug candidates with in vitro and in vivo platforms. For in vivo testing, animal models are used to evaluate the toxicity and efficacy of drug candidates.
Evan Stefanek, Antonia van Rijt, Karolina Valente   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Physical environment in non-ventilated culture vessels affects in vitro growth and morphogenesis of several cultivars of Dianthus Caryophyllus L. [PDF]

, 2002
Differences were shown in the environmental conditions inside four types of non-ventilated culture vessels (glass baby-food jars capped with metal steel or Magenta B-caps, jam glass jars capped with metal steel caps, and Magenta GA7 culture vessels) that
Fall, M. A., Majada Guijo, Juan P., Sánchez Tamés, F.   +2 more
core  

Exploring a patient-specific in vitro pipeline for stratification and drug response prediction of microglia-based therapeutics

Scientific Reports
The scarcity of effective biomarkers and therapeutic strategies for predicting disease onset and progression in neurodegenerative diseases such as Alzheimer’s disease (AD) is a major challenge.
Carla Cuní-López, Romal Stewart, Satomi Okano, Garry L. Redlich, Mark W. Appleby, Anthony R. White, Hazel Quek   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source