Results 61 to 70 of about 130,065,242 (295)

A new in vitro pre-clinical method for testing SARS-CoV-2 nasopharyngeal swabs

Scientific Reports
The SARS-CoV-2 pandemic underscored the critical role of nasopharyngeal swabbing in virus detection and containment. The urgency for mass production of swabs highlighted the necessity to evaluate their efficiency against the global shortage of medical ...
Ian Camilo Orjuela-Garzón, Inés María Fernández-Calderón, María de los Ángeles Ayala, María Alejandra Rodríguez Soto, Camilo Eduardo Pérez-Cualtán, Camila Irene Castro-Paez, Juan C. Cruz, Carolina Muñoz-Camargo, Javier Navarro, Rodrigo Cabrera, Juan C. Briceño   +10 more
doaj   +1 more source

Preclinical developmental toxicity testing and advanced in-vitro stem cell based systems.

, 2021
Therapeutic development and drug discovery processes are heavily challenged by delays in the preclinical experimental stages before being offered for Phase 1 clinical trials. Accelerating the preclinical phase via novel in-vitro systems is need of the hour to help provide effective therapeutics to cure diseases like cancer.
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Supporting data for “Preclinical study of novel targeted agents on nasopharyngeal carcinoma (NPC)”

, 2022
This study has performed experiments to evaluate the antitumor efficacy of different novel targeted agents on preclinical nasopharyngeal carcinoma models.
Ka Yee Li (9067655)
core   +1 more source

Exploring a patient-specific in vitro pipeline for stratification and drug response prediction of microglia-based therapeutics

Scientific Reports
The scarcity of effective biomarkers and therapeutic strategies for predicting disease onset and progression in neurodegenerative diseases such as Alzheimer’s disease (AD) is a major challenge.
Carla Cuní-López, Romal Stewart, Satomi Okano, Garry L. Redlich, Mark W. Appleby, Anthony R. White, Hazel Quek   +6 more
doaj   +1 more source

In vitro, Tissue-Based Models as a Replacement for Animal Models in Testing of Drugs at the Preclinical Stages [PDF]

, 2012
None
Zhanqiu Yang, Hai-Rong Xiong
openaire   +2 more sources

Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests [PDF]

Seminars in Cancer Biology, 2017
This review is part of a special issue entitled "Role of dietary pattern, foods, nutrients and nutraceuticals in supporting cancer prevention and treatment" and describes a pharmacological strategy to determine the potential contribution of food-related components as anticancer agents against established cancer.
Lefranc, Florence, Tabanca, Nurhayat, Kiss, Robert   +2 more
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Innovative preclinical models for pulmonary drug delivery research.

, 2020
Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs.
Vecellio, L., Barosova, Hana, Schmid, O., Schmid, Otmar, Sznitman, Josue, Vecellio, Laurent, Barosova, H., Rothen-Rutishauser, Barbara, Yang, L., Sznitman, J., Henze-Vourc´h, N., Yang, Lin, Ehrmann, S., Mitchell, Jolyon, Heuzé-Vourc'H, Nathalie, Ehrmann, Stephan, Darquenne, Chantal, Heuze-Vourc’h, Nathalie, Darquenne, C., Mitchell, J., Rothen-Rutishauser, B., Rothen-Rutishauser B, Vecellio L, Schmid O, Barosova H, Darquenne C, Heuze-Vourc'h N, Mitchell J, Yang L, Ehrmann S, Sznitman J   +30 more
core   +1 more source

Comparative Analysis of Antidiabetic Activities of Caesalpinia bonducella: Mechanisms, and Therapeutic Applications [PDF]

Research Journal of Pharmacognosy
Caesalpinia bonducella is traditionally used for glycemic control. Evidence from in vitro and animal studies has expanded over the last decade but remains fragmented. This review aimed to evaluate the antidiabetic effects of C.
Ami Febriza*, Fityatun Usman, Andi Ulfah Magefirah Rasyid, Zulkifli Halid, Khairunnisa Akib   +4 more
doaj   +1 more source