Results 51 to 60 of about 114,465,275 (302)

Parenteral Lipid-Based Nanoparticles for CNS Disorders: Integrating Various Facets of Preclinical Evaluation towards More Effective Clinical Translation

Pharmaceutics, 2023
Contemporary trends in combinatorial chemistry and the design of pharmaceuticals targeting brain disorders have favored the development of drug candidates with increased lipophilicity and poorer water solubility, with the expected improvement in delivery
Tanja Ilić, Jelena B. Đoković, Ines Nikolić, Jelena R. Mitrović, Ivana Pantelić, Snežana D. Savić, Miroslav M. Savić   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Development of a Physiologic In-Vitro Testing Methodology for Assessment of Cervical Spine Kinematics [PDF]

, 2013
In-vitro biomechanical testing has been critical in the design and evaluation of spinal surgical instrumentation, however determination of realistic physiologic loading levels has proven difficult outside of the in-vivo setting.
Bell, Kevin
core  

A novel in vitro model for preclinical testing of the hemocompatibility of intravascular stents according to ISO 10993-4

Journal of Materials Science: Materials in Medicine, 2011
Subacute stent thrombosis, caused by undesired interactions between blood and the stent surface, is a major concern in the first few weeks following coronary artery stent implantation. The aim of this study was to establish a novel in vitro model for hemocompatibility testing of coronary artery stents according to ISO 10993-4.
Stefan, Sinn, Torsten, Scheuermann, Stephan, Deichelbohrer, Gerhard, Ziemer, Hans P, Wendel   +4 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests [PDF]

Seminars in Cancer Biology, 2017
This review is part of a special issue entitled "Role of dietary pattern, foods, nutrients and nutraceuticals in supporting cancer prevention and treatment" and describes a pharmacological strategy to determine the potential contribution of food-related components as anticancer agents against established cancer.
Lefranc, Florence, Tabanca, Nurhayat, Kiss, Robert   +2 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Small poly-L-lysines improve cationic lipid-mediated gene transfer in vascular cells in vitro and in vivo [PDF]

, 2007
The potential of two small poly-L-lysines ( sPLLs), low molecular weight sPLL ( LMW-L) containing 7 - 30 lysine residues and L18 with 18 lysine repeats, to enhance the efficiency of liposome-mediated gene transfer ( GT) with cationic lipid DOCSPER {[}1,3-
Pelisek, Jaroslav, Rolland, Pierre-Henri, Nikol, Sigrid, Golda, Adam, Mekkaoui, Choukri, Engelmann, Markus G., Klocke, Rainer, Golda, Adam;Pelisek, Jaroslav;Klocke, Rainer;Engelmann, Markus G.;Rolland, Pierre-Henri;Mekkaoui, Choukri;Nikol, Sigrid, Golda, A;Pelisek, J;Klocke, R;Engelmann, MG;Rolland, PH;Mekkaoui, C;Nikol, S   +8 more
core   +1 more source

A new in vitro pre-clinical method for testing SARS-CoV-2 nasopharyngeal swabs

Scientific Reports
The SARS-CoV-2 pandemic underscored the critical role of nasopharyngeal swabbing in virus detection and containment. The urgency for mass production of swabs highlighted the necessity to evaluate their efficiency against the global shortage of medical ...
Ian Camilo Orjuela-Garzón, Inés María Fernández-Calderón, María de los Ángeles Ayala, María Alejandra Rodríguez Soto, Camilo Eduardo Pérez-Cualtán, Camila Irene Castro-Paez, Juan C. Cruz, Carolina Muñoz-Camargo, Javier Navarro, Rodrigo Cabrera, Juan C. Briceño   +10 more
doaj   +1 more source