Results 21 to 30 of about 114,465,275 (302)
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019.
Rodrigo De Vecchi +8 more
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Roles for In Vitro Myelotoxicity Tests in Preclinical Drug Development and Clinical Trial Planning [PDF]
Toxicologic Pathology, 1993 Myelosuppression is the dose-limiting side effect for most anti-cancer and many anti-human immunodeficiency virus agents, which can be quantitated with optimized colony-forming assays (granulocyte-macrophage, late erythroid, and megakaryocytic [for murine only] colony-forming units and early erythroid burst-forming units (BFUs)).
R E, Parchment +2 more
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Gas transport during in vitro and in vivo preclinical testing of inert gas therapies [PDF]
Medical Gas Research, 2016 New gas therapies using inert gases such as xenon and argon are being studied, which require in vitro and in vivo preclinical experiments. Examples of the kinetics of gas transport during such experiments are analyzed in this paper. Using analytical and numerical models, we analyze an in vitro experiment for gas transport to a 96 cell well plate and an
Katz, Ira +5 more
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Preclinical Safety Assessment: In vitro – in vivo Testing [PDF]
Pharmacology & Toxicology, 2000 Abstract: In vitro– and in vivo preclinical safety tests on drug candidates needed before first dose in man and before marketing authorisation are as follows: The acute and repeated dose toxicity studies, the reproductive toxicity studies, the genotoxicity studies, the carcinogenicity studies and finally the safety pharmacology studies.
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Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery
Biosensors and Bioelectronics: X, 2022 The core of the drug research and screening processes is predicting the effect of drugs prior to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the cost of drug discovery is continuously rising.
Tanvir Ahmed
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Life, 2022 Duchenne muscular dystrophy (DMD) is the most frequent genetic myopathy in childhood and leads to progressive muscle atrophy, weakness, and premature death. So far, there is no curative treatment available.
Tina Donandt +6 more
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Characterization of phototoxicity reactions in human and animal skin models [PDF]
, 2013 Phototoxicity is a relatively common phenomenon and is an adverse effect of some systemic drugs. A large number of pharmaceutical drug substances are known to carry the potential to elicit a phototoxic response (Moore 2002, Ferguson 2002). Reported cases
Boudon, Stéphanie
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Reconstruction of destruction – in vitro reconstitution methods in autophagy research [PDF]
, 2018 International audienceAutophagy is one of the most elaborative membrane remodeling systems in eukaryotic cells. Its major function is to recycle cytoplasmic material by delivering it to lysosomes for degradation.
Wollert, Thomas, Moparthi, Satish Babu
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Developing preclinical models of neuroblastoma: driving therapeutic testing
BMC Biomedical Engineering, 2019 Despite advances in cancer therapeutics, particularly in the area of immuno-oncology, successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common cancer in infants under 1 year of age, and accounts for approximately 10% of all ...
Kimberly J. Ornell, Jeannine M. Coburn
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Nucleic Acid Therapeutics, 2022 Antisense oligonucleotides (ASOs) can modulate pre-mRNA splicing. This offers therapeutic opportunities for numerous genetic diseases, often in a mutation-specific and sometimes even individual-specific manner. Developing therapeutic ASOs for as few as even a single patient has been shown feasible with the development of Milasen for an individual with ...
Aartsma-Rus, A. +8 more
openaire +6 more sources