Results 41 to 50 of about 39,489 (265)
Dados: Revista de Ciências Sociais, 2010 Dans cet article, on souhaite situer et examiner le débat méthodologique proposé par l'École de Cambridge au sujet de l'histoire de la pensée politique dans les quatre dernières décennies, tout en insistant sur les positions de Quentin Skinner et les ...
Ricardo Silva
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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On a Theorem of Ono and Skinner
Journal of Number Theory, 2001 Let \(g(z)=\sum_{n\geq 0} c(n) q^n\) be a Hecke eigenform of half-integral weight with algebraic integer coefficients. In 1998, \textit{K. Ono} and \textit{C. Skinner} [Ann. Math. (2) 147, 453-470 (1998; Zbl 0907.11017)] showed that if a certain condition holds (``\(g(z)\) is good''), then for all but finitely many rational primes \(\ell\) there exist ...
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Significado e interpretação na História das Ideias
Tempo e Argumento, 2017 Tradução do Capítulo 4 da obra: SKINNER, Quentin. Meaning and Understanding in the History of Ideas. In: SKINNER, Quentin. Visions of Politics. Londres: Cambridge University Press, 2001, vol. I, cap. 4, p. 57-89.
Quentin Skinner
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
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SKINNER, POPPER E O SUPOSTO ESTATUTO DETERMINISTA DO COMPORTAMENTALISMO RADICAL
Princípios, 2015 A relação entre Comportamentalismo Radical e determinismo é anunciada por Skinner e diversos comentadores de sua obra. Contudo, há alguns autores que questionam essa relação, defendendo que a ciência do comportamento skinneriana estaria mais próxima do ...
César Antonio Alves da Rocha +2 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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