Results 51 to 60 of about 39,489 (265)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Opvoedkundige Tegnologie / Educational Technology: Geprogrammeerde onderrig: Skinner en Crowder se bydraes

Scientia Militaria, 2012
The article: Programmed Instruction, The Contribution of Skinner and Crowder discusses exactly what is meant by the term Programmed Instruction, and the contribution made by Skinner and Crowder in particular are analysed.
U. Bouwer
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Fronteiras entre análise do comportamento e fisiologia: Skinner e a temática dos eventos privados Boundaries between behavior analysis and physiology: Skinner and the issue of private events

Psicologia: Reflexão e Crítica, 2000
O presente estudo examinou referências de B. F. Skinner à fisiologia em textos sobre eventos privados, com o objetivo de identificar elementos para uma demarcação mais precisa das relações entre análise do comportamento e fisiologia.
Emmanuel Zagury Tourinho, Eveny da Rocha Teixeira, Josiane Miranda Maciel   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Um diálogo entre um cristão ortodoxo e um behaviorista radical

Psicologia: Ciência e Profissão
Este artigo discute a religião através de um diálogo entre dois sujeitos fictícios: Tommaso, um behaviorista radical e defensor da idéia skinneriana de que a religião não se diferencia de outras formas de controle, e Gottlieb, um cristão ortodoxo e ...
Tyffanne Serra Paraná Rodrigues, Alexandre Dittrich   +1 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Book Review: 'Radical Republicanism. Recovering the Tradition’s Popular Heritage' by Bruno Leipold, Karma Nabulsi, and Stuart White (eds.), Oxford University Press, 2020, 268 pages. ISBN: 978-0-19-879672-5

Redescriptions, 2022
Lena Halldenius
doaj   +1 more source

Liberdade e lei no neo-republicanismo de Skinner e Pettit Liberty and law in Skinner and Pettit's neo-republicanism

Lua Nova: Revista de Cultura e Política, 2008
O artigo objetiva analisar as intervenções de Quentin Skinner e de Philip Pettit nas disputas atuais sobre o significado do conceito de liberdade. Argumenta-se que, malgrado diferenças de método e estilo entre os autores, ambos convergem para a defesa de
Ricardo Silva
doaj   +1 more source