Results 61 to 70 of about 497,473 (285)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
, 2005 In dealing with Skinner, we are concerned with a theorist who now espouses no theory, a systematist whose system is still developing, and a constructive thinker some of whose most important contributions have been those of a critic. In the course of his writings, Skinner has presented the results of a comprehensive experimental program, and elaborated
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
SKINNER, POPPER E O SUPOSTO ESTATUTO DETERMINISTA DO COMPORTAMENTALISMO RADICAL
Princípios, 2015 A relação entre Comportamentalismo Radical e determinismo é anunciada por Skinner e diversos comentadores de sua obra. Contudo, há alguns autores que questionam essa relação, defendendo que a ciência do comportamento skinneriana estaria mais próxima do ...
César Antonio Alves da Rocha +2 more
doaj +2 more sources
Scientia Militaria, 2012 The article: Programmed Instruction, The Contribution of Skinner and Crowder discusses exactly what is meant by the term Programmed Instruction, and the contribution made by Skinner and Crowder in particular are analysed.
U. Bouwer
doaj +1 more source
Higher-order Mechanics: Variational Principles and other topics [PDF]
, 2012 After reviewing the Lagrangian-Hamiltonian unified formalism (i.e, the Skinner-Rusk formalism) for higher-order (non-autonomous) dynamical systems, we state a unified geometrical version of the Variational Principles which allows us to derive the ...
A. Echeverría-Enríquez +24 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Worldsheet Geometries of Ambitwistor String
, 2015 Mason and Skinner proposed the ambitwistor string theory which directly reproduces the formulas for the amplitudes of massless particles proposed by Cachazo, He and Yuan.
Ohmori, Kantaro
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source