Results 71 to 80 of about 1,479 (176)

Enteroscopic Balloon Dilation in Small Bowel Stricturing Crohn’s Disease: Long‐Term Outcomes and Risk Factors for Surgery in a Single‐Center Prospective Observational Study

United European Gastroenterology Journal, Volume 13, Issue 6, Page 958-970, July 2025.
ABSTRACT Background and Aims The long‐term outcomes of enteroscopic balloon dilation for small bowel strictures in patients with Crohn’s disease are not well understood. Although Crohn’s strictures can be classified into web‐like, ulcerated, and spindle‐shaped strictures based on endoscopic findings, the outcomes of enteroscopic balloon dilation ...
Sung Noh Hong, Ji Eun Kim, Eun Ran Kim, Dong Kyung Chang, Young‐Ho Kim   +4 more
wiley   +1 more source

A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Primary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation.
Kara Zehr, Morgan Buckley, Joshua W. Owens, Tomas Vanagunas, Patricia Vega Fernandez, Robert J. Hopkin, Amelle Shillington   +6 more
wiley   +1 more source

A Novel Chronic Enteropathy Associated with SLCO2A1 Gene Mutation: Enterography Findings in a Multicenter Korean Registry

, 2023
Objective: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a recently recognized disease. We aimed to evaluate the enterographic findings of CEAS.
Byong Duk Ye, Jihun Kim, Seong Ho Park, Suk-Kyun Yang, Boryeong Jeong   +4 more
core   +1 more source

System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 758-770, April 2025.
It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone, Osayd Zohud, Kareem Midlej, Charles Brenner, Fuad A. Iraqi   +4 more
wiley   +1 more source

BLM-induced pulmonary fibrosis in WT and Slco2a1-/- mice.

, 2015
(A) Slco2a1 protein expression was confirmed by Western blot analysis in lung homogenates prepared from WT and Slco2a1-/- mice. (B) Slco2a1 protein expression was examined by Western blot analysis in lung homogenates from PBS- and BLM-treated WT mice ...
Shin-ichi Akanuma (331229), Tomohiko Wakayama (29594), Ikumi Tamai (333356), Yuka Uetoko (731749), Ken-ichi Hosoya (331230), Takeo Nakanishi (333351), Reo Mimura (731748), Yoshitaka Hasegawa (731747), Hisakazu Komori (731750)   +8 more
core   +1 more source

A Narrative Review on the Effect of Valproic Acid on the Placenta

Birth Defects Research, Volume 117, Issue 4, April 2025.
ABSTRACT Background Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug with well‐established teratogenic risks when taken during pregnancy. While its harmful effects on fetal development are well known, less attention has been given to its impact on placental development and function, despite the placenta's critical role in pregnancy ...
Lauren T. L. Brown, Delaine Pereira, Louise M. Winn   +2 more
wiley   +1 more source

Prostaglandin Transporters ABCC4 and SLCO2A1 in the Uterine Endometrium and Conceptus During Pregnancy in Pigs

Biology of Reproduction, 2014
Prostaglandins (PGs) are involved in many reproductive activities including luteolysis, maternal recognition of pregnancy, endometrial gene expression, conceptus development, and parturition in domestic animals. However, mechanisms by which PGE2 and PGF2alpha are modulated in the uterine endometrium and expression of ABCC4 and SLCO2A1, responsible for ...
Heewon, Seo, Yohan, Choi, Jangsoo, Shim, Inkyu, Yoo, Hakhyun, Ka   +4 more
openaire   +2 more sources

Monogenic SLCO2A1 gene mutation presenting as early onset inflammatory bowel disease-A report of rare case with review of literature

Indian Journal of Pathology and Microbiology
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a rare, autosomal recessive disorder characterized by multiple chronic ulcerative and structuring lesions in the small intestine, primarily affecting the ileum.
Mukund Namdev Sable, M. Shameema Farween, Susama Patra, Saswati Kar, Subash Chandra Samal   +4 more
doaj   +1 more source

Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E‐Cadherin/Krüppel‐Like Factor 4/Integrin α5 Signaling in a Calcium‐Dependent Manner

MedComm, Volume 6, Issue 3, March 2025.
Our findings reveal that Fusobacterium nucleatum increases intracellular Ca2+ concentration, which promotes interaction between E‐cadherin and KLF4, resulting in KLF4 phosphorylation and translocation in the nucleus. The phosphorylated KLF4 induces ITGA5 transcription and activated FAK/PI3K/Akt1 signaling, finally promoting the growth, invasion, and ...
Xuebing Yan, Xiao Qu, Jiaxin Wang, Ling Lu, Wenjuan Wu, Jingxian Mao, Donglin Li, Ying Wang, Qing Wei, Jianqiang Liu   +9 more
wiley   +1 more source

Evaluation of hyponatremia among older adults exposed to selective serotonin reuptake inhibitors and thiazide diuretics

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 3, Page 169-176, March 2025.
Abstract Objective Hyponatremia is a common electrolyte disorder among older adults that can cause serious adverse effects. The purpose of this study was to assess the risk of hyponatremia with the concurrent use of selective serotonin reuptake inhibitors (SSRIs) and thiazide diuretics in an older population.
Trisha Matsuura, Abdelrahaman G. Tawfik, Kenechukwu C. Ben‐Umeh, Philip D. Hansten, Daniel C. Malone   +4 more
wiley   +1 more source