Results 81 to 90 of about 2,152 (193)

Clinical pharmacology and pharmacogenetics of prostaglandin analogues in glaucoma

Frontiers in Pharmacology, 2022
Glaucoma is the main cause of irreversible visual loss worldwide, and comprises a group of progressive, age-related, and chronic optic neuropathies. Prostaglandin analogs are considered a first-line treatment in the management of glaucoma and have the ...
Lin Zhou, Wenyi Zhan, Xin Wei
doaj   +1 more source

A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Primary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation.
Kara Zehr, Morgan Buckley, Joshua W. Owens, Tomas Vanagunas, Patricia Vega Fernandez, Robert J. Hopkin, Amelle Shillington   +6 more
wiley   +1 more source

Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.

PLoS ONE, 2021
[This corrects the article DOI: 10.1371/journal.pone.0241869.].
Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo   +10 more
doaj   +1 more source

System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 758-770, April 2025.
It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone, Osayd Zohud, Kareem Midlej, Charles Brenner, Fuad A. Iraqi   +4 more
wiley   +1 more source

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast

, 2015
The organic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are expressed in the basal membrane of the placental syncytiotrophoblast.
Brooks, S., Cleal, J., Hanson, M., Lewis, R., Lofthouse, Emma, O'Kelly, Ita, Poore, K.   +6 more
core   +1 more source

Monogenic SLCO2A1 gene mutation presenting as early onset inflammatory bowel disease-A report of rare case with review of literature

Indian Journal of Pathology and Microbiology
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a rare, autosomal recessive disorder characterized by multiple chronic ulcerative and structuring lesions in the small intestine, primarily affecting the ileum.
Mukund Namdev Sable, M. Shameema Farween, Susama Patra, Saswati Kar, Subash Chandra Samal   +4 more
doaj   +1 more source

A Narrative Review on the Effect of Valproic Acid on the Placenta

Birth Defects Research, Volume 117, Issue 4, April 2025.
ABSTRACT Background Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug with well‐established teratogenic risks when taken during pregnancy. While its harmful effects on fetal development are well known, less attention has been given to its impact on placental development and function, despite the placenta's critical role in pregnancy ...
Lauren T. L. Brown, Delaine Pereira, Louise M. Winn   +2 more
wiley   +1 more source

The Effect of Thiazide Diuretics on Urinary Prostaglandin E2 Excretion and Serum Sodium in the General Population. [PDF]

J Clin Endocrinol Metab
Context:Thiazide-induced hyponatremia is one of the most common forms of hyponatremia, but its pathogenesis is incompletely understood. Recent clinical data suggest links with prostaglandin E2 (PGE2) and a single nucleotide polymorphism (SNP) in the ...
Geurts F, Rudolphi CF, Pelouto A, van der Burgh AC, Salih M, Imenez Silva PH, Fenton RA, Chaker L, Hoorn EJ.   +8 more
europepmc   +4 more sources

Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis [PDF]

, 2015
published_or_final_versio
Chen, J, Cheuk, IWY, Ho, JC, Kwong, A, Shin, VY, Siu, MT, Tsang, JY, Tse, GM, Wang, X   +8 more
core  

Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E‐Cadherin/Krüppel‐Like Factor 4/Integrin α5 Signaling in a Calcium‐Dependent Manner

MedComm, Volume 6, Issue 3, March 2025.
Our findings reveal that Fusobacterium nucleatum increases intracellular Ca2+ concentration, which promotes interaction between E‐cadherin and KLF4, resulting in KLF4 phosphorylation and translocation in the nucleus. The phosphorylated KLF4 induces ITGA5 transcription and activated FAK/PI3K/Akt1 signaling, finally promoting the growth, invasion, and ...
Xuebing Yan, Xiao Qu, Jiaxin Wang, Ling Lu, Wenjuan Wu, Jingxian Mao, Donglin Li, Ying Wang, Qing Wei, Jianqiang Liu   +9 more
wiley   +1 more source