Sleeping sickness is a circadian disorder [PDF]
Nature Communications, 2018 African sleeping sickness is well known for the alterations of sleeping patterns, but it is not known how circadian biology is altered by the causative pathogen Trypanosoma brucei. Here the authors show T.
Filipa Rijo-Ferreira +6 more
doaj +9 more sources
Sleeping Sickness: A Tale of Two Clocks [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature ...
Filipa Rijo-Ferreira +3 more
doaj +3 more sources
Including refugees in disease elimination: challenges observed from a sleeping sickness programme in Uganda [PDF]
Conflict and Health, 2017 Background Ensuring equity between forcibly-displaced and host area populations is a key challenge for global elimination programmes. We studied Uganda’s response to the recent refugee influx from South Sudan to identify key governance and operational ...
Jennifer J. Palmer +2 more
doaj +5 more sources
The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History [PDF]
Tropical Medicine and Infectious Disease, 2020 With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’ ...
Harry P. De Koning
doaj +4 more sources
We Remember… Elders' Memories and Perceptions of Sleeping Sickness Control Interventions in West Nile, Uganda. [PDF]
PLoS Neglected Tropical Diseases, 2016 The traditional role of African elders and their connection with the community make them important stakeholders in community-based disease control programmes.
Vanja Kovacic +6 more
doaj +8 more sources
Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo. [PDF]
Nat Commun, 2022 Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission by 2030. While annual new cases are at a historical minimum, the likelihood of achieving the target is unknown.
Huang CI +7 more
europepmc +2 more sources
The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. [PDF]
PLoS Neglected Tropical Diseases, 2013 Tsetse-transmitted human and animal trypanosomiasis are constraints to both human and animal health in sub-Saharan Africa, and although these diseases have been known for over a century, there is little recent evidence demonstrating how the parasites ...
Nicola A Wardrop +3 more
doaj +4 more sources
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System. [PDF]
J Neurosci, 2020 Patients with sleeping sickness, caused by the parasite Trypanosoma brucei, have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood.
Rijo-Ferreira F +5 more
europepmc +2 more sources
Tsetse elimination: its interest and feasibility in the historical sleeping sickness focus of Loos islands, Guinea [PDF]
Parasite, 2009 Guinea is the West African country which is currently the most prevalent for sleeping sickness. The littoral area is the region where most of the recent sleeping sickness cases have been described, especially the mangrove sleeping sickness foci of ...
Kagbadouno M. +8 more
doaj +3 more sources
Screening Strategies for a Sustainable Endpoint for Gambiense Sleeping Sickness. [PDF]
J Infect Dis, 2020 Background Gambiense human African trypanosomiasis ([gHAT] sleeping sickness) is a vector-borne disease that is typically fatal without treatment. Intensified, mainly medical-based, interventions in endemic areas have reduced the occurrence of gHAT to ...
Castaño MS +5 more
europepmc +2 more sources