Results 21 to 30 of about 140,774 (244)

Estimates of the duration of the early and late stage of gambiense sleeping sickness [PDF]

, 2008
Background: The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2 (late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due to Trypanosoma brucei gambiense are poorly quantified, but key to ...
Filipe, João AN, Haydon Daniel T, Filipe João AN, Chappuis, F., Checchi Francesco, Haydon, D.T., Checchi, F, Checchi, Francesco, Chandramohan, D, Chappuis, F, Chandramohan, Daniel, Filipe, J A N, Filipe, João A N., Haydon, Daniel T, Haydon, D T, Filipe, J.A., Haydon, Daniel T., Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +21 more
core   +3 more sources

In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness [PDF]

, 2012
Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Kisala, M, Schmid, C., Kisala, M., Mordt, O. V., Ismael Lumpungu, Mutanda, S, Mays Kisala, Kande, V, Nganzobo Pathou, Kuemmerle Andrea, Blum Johannes, Medard Ilunga, Nono Mubwa, Lumpungu Ismael, Mubwa Nono, Mordt Olaf Valverde, Schmid Caecilia, Mubwa, N, Blesson Severine, Wilfried Mutombo, Nganzobo, P., Mutombo Wilfried, Victor Kande, Mordt, O V, Tete Digas, Tete, D, Blesson, S, Kümmerle, A., Ilunga Medard, Schmid, C, Ilunga, M., Kuemmerle, A, Sylvain Mutanda, Ghabri, S, Ghabri, S., Andrea Kuemmerle, Lumpungu, I, Salah Ghabri, Kande, V., Johannes Blum, Lumpungu, I., Ghabri Salah, Blum, J, Digas Tete, Mubwa, N., Mutanda, S., Pathou Nganzobo, Ilunga, M, Caecilia Schmid, Tete, D., Nganzobo, P, Blum, J., Mutombo, W., Mutanda Sylvain, Kisala Mays, Blésson, S., Olaf Valverde Mordt, Severine Blesson, Kande Victor, Mutombo, W   +59 more
core   +1 more source

Late stage infection in sleeping sickness. [PDF]

PLoS ONE, 2012
At the turn of the 19(th) century, trypanosomes were identified as the causative agent of sleeping sickness and their presence within the cerebrospinal fluid of late stage sleeping sickness patients was described.
Hartwig Wolburg, Stefan Mogk, Sven Acker, Claudia Frey, Monika Meinert, Caroline Schönfeld, Michael Lazarus, Michael Lazarus, Yoshihiro Urade, Bruno Kilunga Kubata, Michael Duszenko   +10 more
doaj   +1 more source

The natural progression of gambiense sleeping sickness: what is the evidence? [PDF]

, 2008
Gambiense human African trypanosomiasis (HAT, sleeping sickness) is widely assumed to be 100% pathogenic and fatal. However, reports to the contrary exist, and human trypano-tolerance has been postulated.
Filipe, João AN, Francesco Checchi, Barrett, M.P., Daniel Chandramohan, Checchi Francesco, Barrett, Michael P, Checchi, Francesco, Filipe, J.A.N., Chandramohan, Daniel, João A N Filipe, Barrett Michael P., Michael P Barrett, Filipe João A. N., Checchi, F., Chandramohan, D., Chandramohan Daniel   +15 more
core   +2 more sources

Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon

The Pan African Medical Journal, 2011
BACKGROUND: Knowledge about transmission of sleeping sickness in a given focus is of a great importance since it governs the efficacy and the cost-effectiveness of control strategy.
Lisette Kohagne Tongué, Paulette Mengue M’eyi, Raceline Gounoue Kamkuimo, Dramane Kaba, Francis J Louis, Rémy Mimpfoundi   +5 more
doaj   +1 more source

In vitro studies and in vivo evaluation of novel diamidines for 2nd stage sleeping sickness [PDF]

, 2014
Summary: African sleeping sickness is one of the most neglected tropical diseases. Transmitted by the tsetse fly it exclusively occurs in sub-Saharan Africa.
Wenzler, Tanja
core   +1 more source

Global stability analysis of the disease-free equilibrium state of a mathematical model of trypanosomiasis

Journal of Applied Sciences and Environmental Management, 2019
The global stability analysis represents a compound failure, mechanism which provides lower calculated factors of safety. In this research, the global stability analysis was used to propose a mathematically model of the transmission dynamics and control
K.M. Bello, I.N. Akinwande, S Abdurhman, A.F. Kuta, Y Bello   +4 more
doaj   +1 more source

Sleeping sickness [PDF]

, 2011
Artyicle approval pendingHuman African trypanosomiasis (HAT), or sleeping sickness, is a vector-borne disease that flourishes in impoverished, rural parts of sub-Saharan Africa. It is caused by infection with the protozoan parasite Trypanosoma brucei and
Chappuis, F, D. Malvy, Chappuis, F., Malvy, D., Malvy, D, Chappuis, François, F. Chappuis   +6 more
core   +1 more source

Tsetse elimination: its interest and feasibility in the historical sleeping sickness focus of Loos islands, Guinea

Parasite, 2009
Guinea is the West African country which is currently the most prevalent for sleeping sickness. The littoral area is the region where most of the recent sleeping sickness cases have been described, especially the mangrove sleeping sickness foci of ...
Kagbadouno M., Camara M., Bouyer J., Hervouet J.P., Courtin F., Jamonneau V., Morifaso O., Kaba D., Solano P.   +8 more
doaj   +1 more source

A two-stage solution

eLife, 2021
The parasite that causes African sleeping sickness can be transmitted from mammals to tsetse flies in two stages of its lifecycle, rather than one as was previously thought.
Fabien Guegan, Luisa Figueiredo
doaj   +1 more source