The dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area. [PDF]
PLoS Neglected Tropical Diseases, 2013 Tsetse-transmitted human and animal trypanosomiasis are constraints to both human and animal health in sub-Saharan Africa, and although these diseases have been known for over a century, there is little recent evidence demonstrating how the parasites ...
Nicola A Wardrop +3 more
doaj +2 more sources
Reanalyzing the 1900–1920 Sleeping Sickness Epidemic in Uganda [PDF]
Emerging Infectious Diseases, 2004 Sleeping sickness has long been a major public health problem in Uganda. From 1900 to 1920, more than 250,000 people died in an epidemic that affected the southern part of the country, particularly the Busoga region.
E.M. Fèvre +3 more
doaj +2 more sources
Implications of Heterogeneous Biting Exposure and Animal Hosts on Trypanosomiasis brucei gambiense Transmission and Control. [PDF]
PLoS Computational Biology, 2015 The gambiense form of sleeping sickness is a neglected tropical disease, which is presumed to be anthroponotic. However, the parasite persists in human populations at levels of considerable rarity and as such the existence of animal reservoirs has been ...
Chris M Stone, Nakul Chitnis
doaj +3 more sources
Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness [PDF]
, 2012 Disruption of glycosylphosphatidylinositol biosynthesis is genetically and chemically validated as a drug target against the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness.
Crossman, Arthur T. +4 more
core +5 more sources
Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. [PDF]
, 2006 OBJECTIVES: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
Louga, Albino +23 more
core +1 more source
Spatial Analysis of Sleeping Sickness, Southeastern Uganda, 1970–2003
Emerging Infectious Diseases, 2006 Sleeping sickness reemerged in southeastern Uganda in the 1970s and remains a public health problem. It has continued to spread north into new districts, and gaps remain in the understanding of the causes of its spread and distribution.
Lea Berrang-Ford +4 more
doaj +1 more source
Nifurtimox plus eflornithine for late-stage sleeping sickness in Uganda: A case series [PDF]
, 2007 Background: We report efficacy and safety outcomes from a prospective case series of 31 late-stage T. b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+ E) in Yumbe ...
Thomas, F +23 more
core +2 more sources
Civil conflict and sleeping sickness in Africa in general and Uganda in particular
Conflict and Health, 2007 Conflict and war have long been recognized as determinants of infectious disease risk. Re-emergence of epidemic sleeping sickness in sub-Saharan Africa since the 1970s has coincided with extensive civil conflict in affected regions.
Berrang Ford Lea
doaj +1 more source
Diagnostic accuracy of PCR in gambiense sleeping sickness diagnosis, staging and post-treatment follow-up: a 2-year longitudinal study. [PDF]
PLoS Neglected Tropical Diseases, 2011 BACKGROUND:The polymerase chain reaction (PCR) has been proposed for diagnosis, staging and post-treatment follow-up of sleeping sickness but no large-scale clinical evaluations of its diagnostic accuracy have taken place yet.
Stijn Deborggraeve +7 more
doaj +1 more source
Conflict and Health, 2017 Background Ensuring equity between forcibly-displaced and host area populations is a key challenge for global elimination programmes. We studied Uganda’s response to the recent refugee influx from South Sudan to identify key governance and operational ...
Jennifer J. Palmer +2 more
doaj +1 more source