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Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon
BACKGROUND: Knowledge about transmission of sleeping sickness in a given focus is of a great importance since it governs the efficacy and the cost-effectiveness of control strategy.
Lisette Kohagne Tongué+5 more
doaj +1 more source
The global stability analysis represents a compound failure, mechanism which provides lower calculated factors of safety. In this research, the global stability analysis was used to propose a mathematically model of the transmission dynamics and control
K.M. Bello+4 more
doaj +1 more source
Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer+32 more
core +1 more source
Assessing Strategies Against Gambiense Sleeping Sickness Through Mathematical Modeling
Background Control of gambiense sleeping sickness relies predominantly on passive and active screening of people, followed by treatment. Methods Mathematical modeling explores the potential of 3 complementary interventions in high- and low-transmission ...
K. Rock+11 more
semanticscholar +1 more source
The parasite that causes African sleeping sickness can be transmitted from mammals to tsetse flies in two stages of its lifecycle, rather than one as was previously thought.
Fabien Guegan, Luisa Figueiredo
doaj +1 more source
Through the dark continent: African trypanosome development in the tsetse fly [PDF]
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core +4 more sources
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania spp.
Shilpi Khare+36 more
semanticscholar +1 more source