Results 51 to 60 of about 93,900 (314)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Sliding-mode-based robust output regulation and its application in PMSM servo systems

open access: yes, 2022
A robust output regulation of a control system aims at disturbance rejection and reference tracking in the presence of uncertainties. Technically, the control design contains two mechanisms: the compensation of nontrivial steady states caused by ...
Jun Yang (4410343)   +4 more
core   +1 more source

Disturbance attenuation–based sliding mode control with disturbance observer for mismatched uncertain system

open access: yesAdvances in Mechanical Engineering, 2017
A disturbance attenuation–based sliding mode control approach with an extended disturbance observer is proposed for systems with mismatched uncertainties. A novel adaptive sliding surface consisting of the disturbance estimation is presented to eliminate
Jianguo Guo   +3 more
doaj   +1 more source

Disturbance Observer-Based Control to Guarantee a Sliding Mode Without Sliding Mode Control

open access: yesIEEE Access, 2023
This paper presents a novel disturbance observer (DOB)-based control method to prevent the deterioration of transient response due to disturbances. The proposed method uses sliding mode dynamics without a sliding mode control (SMC) structure and does not
Keonwoo Lee, Jaejun Cha, Seungkyu Park
doaj   +1 more source

Genetic-based sliding mode fuzzy controller design [PDF]

open access: yes, 2010
In this paper, we proposed a genetic-based sliding mode fuzzy controller design method to avoid the chattering phenomena in traditional sliding mode controller (SMC), and shorten the hitting time of the controlled system.
翁慶昌; Wong, Ching-chang; Huang, Bing-chyi; Lai, Hung-ren
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Application on the Series Multi-cells Converter for Implementation and Comparison between a Higher Order Sliding Mode Control and Simple Order [PDF]

open access: yesJournal of Electrical and Electronics Engineering, 2015
In this paper, a sliding mode control of a series multi-cells converter is introduced. Multi-cells topologies have gained a lot of popularity because of their advantages over classical energy conversion structures.
SKENDER Mohamed Redha   +1 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Robust sliding mode control for discrete stochastic systems with mixed time delays, randomly occurring uncertainties, and randomly occurring nonlinearities

open access: yes, 2012
This is the post-print version of the paper. The official published version can be accessed from the link below - Copyright @ 2012 IEEEThis paper investigates the robust sliding mode control (SMC) problem for a class of uncertain nonlinear stochastic ...
Zidong Wang   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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