Results 31 to 40 of about 5,377 (266)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A Robust Observer-Based Control Strategy for n-DOF Uncertain Robot Manipulators with Fixed-Time Stability

Sensors, 2021
In this paper, a robust observer-based control strategy for n-DOF uncertain robot manipulators with fixed-time stability was developed. The novel fixed-time nonsingular sliding mode surface enables control errors to converge to the equilibrium point ...
Anh Tuan Vo, Thanh Nguyen Truong, Hee-Jun Kang, Mien Van   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Output current observation and control of grid-connected modular multilevel converter using a simplified super twisting algorithm sliding mode

Results in Engineering
This paper presents a method for observing and controlling the output current of a grid-connected Modular Multilevel Converter (MMC) using a Simplified Super Twisting Algorithm-Sliding Mode (SSTA-SM).
Imane Alia, Imad Merzouk, Mehamed Mounir Rezaoui, Hegazy Rezk, Abderezak Lashab   +4 more
doaj   +1 more source

Disturbance Observer-Based Discrete Sliding-Mode Control for a Marine Diesel Engine with Variable Sampling Control Technique

Journal of Control Science and Engineering, 2020
This paper proposes a disturbance observer-based discrete sliding-mode control scheme with the variable sampling rate control for the marine diesel engine speed control in the presence of system uncertainties and disturbances.
Xuemin Li, Yufei Liu, Haoyu Shu, Runzhi Wang, Yunlong Yang, Chunyue Feng   +5 more
doaj   +1 more source

Time-Delay Luenberger Observer Design for Sliding Mode Control of Nonlinear Markovian Jump Systems via Event-Triggered Mechanism

Machines, 2021
This paper is focused on the stabilization of Takagi–Sugeno fuzzy model-based Markovian jump systems with the aid of a delayed state observer. Due to network-induced constraints in the communication channel, a delay partition method combined with an ...
Min Cheng, Chunyang Zhang, Jin Qiu, Zhengtian Wu, Qing Gao   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A non-singular sliding mode controller for quadrotor attitude with predefined time disturbance observer

Advances in Mechanical Engineering
In this paper, a quadrotor attitude controller based on a predefined time disturbance observer and non-singular predefined time sliding mode is proposed to reject unknown disturbances.
Jingxin Dou, Dongwu Xie, Yingliang Wu, Ti Zhang   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source