Results 51 to 60 of about 4,756 (268)

Fast Finite-Time Super-Twisting Sliding Mode Control with an Extended State Higher-Order Sliding Mode Observer for UUV Trajectory Tracking

Drones
This paper proposes a trajectory tracking control scheme consisting of a fast finite-time super-twisting sliding mode control (FSTSMC) approach and an extended state higher-order sliding mode observer (ESHSMO) for unmanned underwater vehicles (UUVs) with
Liwei Guo, Weidong Liu, Le Li, Jingming Xu, Kang Zhang, Yuang Zhang   +5 more
doaj   +1 more source

Robust Super-Twisting Sliding Control of PAM- actuated Manipulator Based on Perturbation Observer

Cogent Engineering, 2020
This paper addresses the tracking control problem of a single-arm manipulator actuated by Pneumatic Artificial Muscle (PAM) subjected to perturbation in parameters.
Alaq Falah, Amjad J. Humaidi, Ayad Al-Dujaili, Ibraheem Kasim Ibraheem   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Accelerated Adaptive Second Order Super-Twisting Sliding Mode Observer

IEEE Access, 2019
An accelerated second-order super-twisting sliding mode observer with an adaptive gain is proposed for a typical nonlinear system. The key contribution of this algorithm is that the rate of convergence of observation error is accelerated remarkably by ...
Cheng Lin, Shengxiong Sun, Paul Walker, Nong Zhang   +3 more
doaj   +1 more source

Observer-based sliding mode control for discrete nonlinear systems with packet losses: an event-triggered method

Systems Science & Control Engineering, 2020
In this paper, the observer-based output feedback sliding mode control (SMC) problem is investigated for discrete delayed nonlinear systems subject to packet losses under the event-triggered strategy. It is assumed that the packet losses may occur in the
Xinyu Guan, Jun Hu, Yunfei Cui, Long Xu
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Research on Control Strategy of Permanent Magnet Synchronous Motor Based on Fast Terminal Super-Twisting Sliding Mode Observer

IEEE Access
The sliding mode observer (SMO) has the advantages of small influence by parameter changes and strong robustness, which is widely used in the sensorless control of permanent magnet synchronous motor (PMSM). However, when the sliding mode observer is used
Sen Wang, Haiyang Wang, Chong Tang, Jiaxin Li, Daili Liang, Yanhua Qu   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source