Results 251 to 260 of about 165,371 (351)

Molecular mechanisms of skeletal muscle fibrosis and potential targeted therapeutic strategies. [PDF]

Front Immunol
Gong J, Xu J, Zhang J, Shen Y, Sun H, Chen B.   +5 more
europepmc   +1 more source

Tiotropium bromide inhibits TGF-ß-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro

, 2010
Kazuhito Asano
openalex   +2 more sources

Advances in the genetics of refractive errors: Contributions from the CREAM consortium

Acta Ophthalmologica, EarlyView.
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li, Xi He, Louise Terry, Virginie J. M. Verhoeven, Samantha Sze‐Yee Lee, Gareth Lingham, Jeremy A. Guggenheim, David A. Mackey, Seang‐Mei Saw, Caroline C. W. Klaver, Chi Pui Pang, CREAM Consortium   +11 more
wiley   +1 more source

Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling. [PDF]

Front Endocrinol (Lausanne)
Son Y, Byeon HE, Choi SE, Kim Y, Heo YJ, Kwon SB, Choi J, Han SJ, Jeon J, Kim HJ, Lee N, Lee KW.   +11 more
europepmc   +1 more source

HLTF suppresses the migration and invasion of colorectal cancer cells via TGF‑β/SMAD signaling in vitro

, 2018
Li Liu, Huan Liu, Yangying Zhou, Jiaofeng He, Qiong Liu, Jian Wang, Manting Zeng, Dan Yuan, Fengbo Tan, Yuan Zhou, Haiping Pei, Hong Zhu   +11 more
openalex   +2 more sources

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Beyond Organ-Specific Therapies: A Unified Approach to Multi-Organ Fibrosis. [PDF]

Drug Des Devel Ther
Pan Z, Zerehpoosh S, Wang SC, Örmeci N, Kim W, Eslam M.   +5 more
europepmc   +1 more source

KRAB Zinc‐Finger Protein ZNF205 Promotes Hepatocellular Carcinoma via p53 Pathway Repression

Cancer Science, EarlyView.
ZNF205 functions as a critical oncogenic regulator in hepatocellular carcinoma (HCC), where it interacts with p53 and functionally suppresses its transcriptional activity by competitively inhibiting p53 binding to target gene promoters. This p53 inactivation mechanism critically contributes to tumor progression in HCC. ABSTRACT The tumor suppressor p53
Xiaofen Huang, Yingchuan Yang, Yuan Ma, Wei Hao, Jingzhuo Jin, Yue Ding, Yiming Zhang, Xiuyuan Zhang, Xinli Li, Qin Song, Jiaqi Liu, Bingxin Liu, Yuanjun Zhai, Chunling Zhao, Jin Wu, Chunyan Tian   +15 more
wiley   +1 more source

CTHRC1/TGF-β/Smad axis serves as therapeutic targets in inhibiting oral squamous cell carcinoma by mediating ferroptosis. [PDF]

Discov Oncol
Huang S, Jiao Y, Chang Y, Feng Y, Mu G, Xie L.   +5 more
europepmc   +1 more source

SMURF1 Regulates CTCF‐HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
Our study showed that SMURF1 was significantly upregulated in nasopharyngeal carcinoma (NPC) and promoted tumor progression and SMURF1 promoted K48‐linked ubiquitination degradation of CTCF. ABSTRACT The aberrant upregulation of Homeobox A10 (HOXA10) has been implicated in the progression of nasopharyngeal carcinoma (NPC), but the mechanisms driving ...
Ying Jin, Tian Zhang, Zhimin Wu, Yuanshan Liang, Yiting Jiang, Guodong Yu   +5 more
wiley   +1 more source